Propensity score matching and inverse probability of treatment weighting to address confounding by indication in comparative effectiveness research of oral anticoagulants

被引：127

作者：

Allan, Victoria ^{[1
]}

Ramagopalan, Sreeram, V ^{[1
]}

Mardekian, Jack ^{[2
]}

Jenkins, Aaron ^{[3
]}

Li, Xiaoyan ^{[4
]}

Pan, Xianying ^{[5
]}

Luo, Xuemei ^{[6
]}

机构：

[1] Bristol Myers Squibb, Ctr Observat Res & Data Sci, Uxbridge, Middx, England

[2] Pfizer Inc, Stat Global Biometr & Data Management, New York, NY USA

[3] Pfizer Ltd, Patient Hlth & Impact, Outcomes & Evidence, Tadworth, England

[4] Bristol Myers Squibb, Worldwide Hlth Econ & Outcomes Res, Lawrenceville, NJ USA

[5] Bristol Myers Squibb, Pharmacoepidemiol, Lawrenceville, NJ USA

[6] Pfizer Inc, Patient Hlth & Impact, Outcomes & Evidence, Groton, CT 06340 USA

来源：

JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH | 2020年 / 9卷 / 09期

关键词：

atrial fibrillation; comparative effectiveness research; confounding by indication; inverse probability of treatment weighting; oral anticoagulants; propensity score matching; NONVALVULAR ATRIAL-FIBRILLATION; REAL-WORLD DATA; CAUSAL INFERENCE; STROKE PREVENTION; TASK-FORCE; WARFARIN; SAFETY; METAANALYSIS; DABIGATRAN; TUTORIAL;

D O I：

10.2217/cer-2020-0013

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

After decades of warfarin being the only oral anticoagulant (OAC) widely available for stroke prevention in atrial fibrillation, four direct OACs (apixaban, dabigatran, edoxaban and rivaroxaban) were approved after demonstrating noninferior efficacy and safety versus warfarin in randomized controlled trials. Comparative effectiveness research of OACs based on real-world data provides complementary information to randomized controlled trials. Propensity score matching and inverse probability of treatment weighting are increasingly popular methods used to address confounding by indication potentially arising in comparative effectiveness research due to a lack of randomization in treatment assignment. This review describes the fundamentals of propensity score matching and inverse probability of treatment weighting, appraises differences between them and presents applied examples to elevate understanding of these methods within the atrial fibrillation field.

引用

页码：603 / 614

页数：12

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