Insights into the Roles of Cyclophilin A During Influenza Virus Infection

被引：27
作者：
Liu, Xiaoling [1 ]
Zhao, Zhendong [1 ]
Liu, Wenjun [1 ]
机构：
[1] Chinese Acad Sci, Inst Microbiol, Ctr Mol Virol, Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China
来源：
VIRUSES-BASEL | 2013年 / 5卷 / 01期
基金：
中国国家自然科学基金;
关键词：
influenza virus; Cyclophilin A; Cyclosporin A; virus-host interaction; CIS-TRANS-ISOMERASES; MATRIX PROTEIN; HIV-1; VPR; M1; PROTEIN; IDENTIFICATION; REPLICATION; EXPRESSION; INTERACTS; CELLS; RESISTANCE;
D O I：
10.3390/v5010182
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Cyclophilin A (CypA) is the main member of the immunophilin superfamily that has peptidyl-prolyl cis-trans isomerase activity. CypA participates in protein folding, cell signaling, inflammation and tumorigenesis. Further, CypA plays critical roles in the replication of several viruses. Upon influenza virus infection, CypA inhibits viral replication by interacting with the M1 protein. In addition, CypA is incorporated into the influenza virus virions. Finally, Cyclosporin A (CsA), the main inhibitor of CypA, inhibits influenza virus replication through CypA-dependent and -independent pathways. This review briefly summarizes recent advances in understanding the roles of CypA during influenza virus infection.
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收藏
页码：182 / 191
页数：10
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