Gold-coated iron oxide nanoparticles as a potential photothermal therapy agent to enhance eradication of breast cancer cells

被引：32
|
作者：
Dheyab, M. A. [1 ,2 ]
Aziz, A. A. [1 ,2 ]
Jameel, M. S. [1 ,2 ]
Khaniabadi, P. M. [1 ,2 ]
Mehrdel, B. [1 ,2 ]
Khaniabadi, M. [3 ]
机构：
[1] Univ Sains Malaysia, Inst Res Mol Med INFORMM, Nanobiotechnol Res & Innovat NanoBRI, George Town 11800, Malaysia
[2] Univ Sains Malaysia, Sch Phys, Nanooptoelect Res & Technol Lab, George Town 11800, Malaysia
[3] Isfahan Univ Med Sci, Res Inst Primordial Prevent Noncommunicable Dis, Child Growth & Dev Res Ctr, Esfahan, Iran
来源：
11TH INTERNATIONAL SEMINAR ON MEDICAL PHYSICS (ISMP) 2019 | 2020年 / 1497卷
关键词：
IN-VITRO;
D O I：
10.1088/1742-6596/1497/1/012003
中图分类号：
R445 [影像诊断学];
学科分类号：
100207 ;
摘要：
Iron oxide nanoparticles (Fe3O4 NPs) possess unique physicochemical properties which make them great for biomedical applications. This study reports the development of gold (Au) coated Fe3O4 (Au-Fe3O4 NPs) for photothermal therapy to eradicate breast cancer cells (MCF-7). The spherical shape of monodisperse Au-Fe3O4 NPs with an average size of 20.8 nm was confirmed by TEM. The cell viability evaluation of Au-Fe3O4 NPs showed negligible toxicity toward MCF-7 cells after 24 h. Significant cell reduction was observed for MCF-7 (73.9%) cells following photothermal therapy at highest concentration of NPs (50 mu gFe/ml) for 10 minutes illumination when compared with other intervention groups. It can be concluded that, the synthesized Au-Fe3O4 NPs is an effective and promising photothermal therapy agent for breast cancer treatment.
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页数：4
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