Inclusion Body Myositis

被引：43

作者：

Dimachkie, Mazen M. ^{[1
]}

Barohn, Richard J. ^{[1
]}

机构：

[1] Univ Kansas, Med Ctr, Dept Neurol, Kansas City, KS 66160 USA

来源：

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS | 2013年 / 13卷 / 01期

关键词：

Inclusion body myositis; Idiopathic inflammatory myopathies; Polymyositis; Pathology; Pathophysiology; Treatment; Prognosis; PILOT TRIAL; CLINICAL-COURSE; MUSCLE; EPIDEMIOLOGY; LITHIUM; CELLS; BETA;

D O I：

10.1007/s11910-012-0321-4

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Sporadic inclusion body myositis (IBM) is the most common idiopathic inflammatory myopathy (IIM) after age 50 years. It presents with chronic insidious proximal leg and distal arm asymmetric muscle weakness. Despite similarities with polymyositis (PM), it is likely that IBM is primarily a degenerative disorder rather than inflammatory muscle disease. IBM is associated with a modest degree of creatine kinase (CK) elevation and an electromyogram (EMG) demonstrates a chronic irritative myopathy. Muscle histopathology demonstrates endomysial inflammatory exudates surrounding and invading non-necrotic muscle fibers often times accompanied by rimmed vacuoles. We review IBM with emphasis on recent developments in the field and discuss ongoing clinical trials.

引用

页数：9

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