Genome-wide association study identifies 48 common genetic variants associated with handedness

被引：99

作者：

Cuellar-Partida, Gabriel ^{[1
,2
]}

Tung, Joyce Y. ^{[2
]}

Eriksson, Nicholas ^{[2
]}

Albrecht, Eva ^{[3
]}

Aliev, Fazil ^{[4
,5
]}

Andreassen, Ole A. ^{[6
,7
]}

Barroso, Ines ^{[8
,9
,10
]}

Beckmann, Jacques S. ^{[11
,12
]}

Boks, Marco P. ^{[13
]}

Boomsma, Dorret I. ^{[14
,15
]}

Boyd, Heather A. ^{[16
]}

Breteler, Monique M. B. ^{[17
]}

Campbell, Harry ^{[18
]}

Chasman, Daniel I. ^{[19
,20
]}

Cherkas, Lynn F. ^{[21
]}

Davies, Gail ^{[22
,23
]}

de Geus, Eco J. C. ^{[14
,15
]}

Deary, Ian J. ^{[22
,23
]}

Deloukas, Panos ^{[24
,25
]}

Dick, Danielle M. ^{[4
,26
]}

Duffy, David L. ^{[27
]}

Eriksson, Johan G. ^{[28
,29
,30
,31
,32
]}

Esko, Tonu ^{[33
,34
]}

Feenstra, Bjarke ^{[16
]}

Geller, Frank ^{[16
]}

Gieger, Christian ^{[35
,36
]}

Giegling, Ina ^{[37
,38
]}

Gordon, Scott D. ^{[27
]}

Han, Jiali ^{[39
,40
]}

Hansen, Thomas F. ^{[41
,42
]}

Hartmann, Annette M. ^{[37
,38
]}

Hayward, Caroline ^{[43
]}

Heikkila, Kauko ^{[44
]}

Hicks, Andrew A. ^{[45
]}

Hirschhorn, Joel N. ^{[46
,47
,48
]}

Hottenga, Jouke-Jan ^{[14
,15
]}

Huffman, Jennifer E. ^{[43
]}

Hwang, Liang-Dar ^{[1
]}

Ikram, M. Arfan ^{[49
]}

Kaprio, Jaakko ^{[44
,50
]}

Kemp, John P. ^{[1
,51
]}

Khaw, Kay-Tee ^{[52
]}

Klopp, Norman ^{[53
]}

Konte, Bettina ^{[37
,38
]}

Kutalik, Zoltan ^{[54
,55
]}

Lahti, Jari ^{[56
,57
,58
]}

Li, Xin ^{[39
,40
]}

Loos, Ruth J. F. ^{[9
,59
,60
]}

Luciano, Michelle ^{[22
,23
]}

Magnusson, Sigurdur H. ^{[61
]}

机构：

[1] Univ Queensland, Diamantina Inst, Woolloongabba, Qld, Australia

[2] 23andMe Inc, Sunnyvale, CA USA

[3] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Genet Epidemiol, Neuherberg, Germany

[4] Virginia Commonwealth Univ, Dept Psychol, Box 2018, Richmond, VA 23284 USA

[5] Karabuk Univ, Fac Business, Karabuk, Turkey

[6] Univ Oslo, Inst Clin Med, NORMENT, Oslo, Norway

[7] Oslo Univ Hosp, Div Mental Hlth & Addict, Oslo, Norway

[8] Wellcome Sanger Inst, Human Genet, Hinxton, England

[9] Univ Cambridge, MRC Epidemiol Unit, Cambridge, England

[10] Univ Cambridge, Wellcome MRC Inst Metab Sci, Cambridge, England

[11] CHU Vaudois, Serv Med Genet, Lausanne, Switzerland

[12] Univ Lausanne, Lausanne, Switzerland

[13] Univ Utrecht, UMC Utrecht Brain Ctr, Dept Psychiat, Utrecht, Netherlands

[14] Vrije Univ, Dept Biol Psychol, Amsterdam, Netherlands

[15] Univ Amsterdam, Amsterdam Publ Hlth Res Inst, Med Ctr, Amsterdam, Netherlands

[16] Statens Serum Inst, Dept Epidemiol Res, Copenhagen, Denmark

[17] German Ctr Neurodegenerat Dis DZNE, Populat Hlth Sci, Bonn, Germany

[18] Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland

[19] Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA

[20] Harvard Med Sch, Boston, MA 02115 USA

[21] Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England

[22] Univ Edinburgh, Dept Psychol, Edinburgh, Midlothian, Scotland

[23] Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland

[24] Queen Mary Univ London, William Harvey Res Inst, Barts & London Med Sch, London, England

[25] Queen Mary Univ London, Ctr Genom Hlth, London, England

[26] Virginia Commonwealth Univ, Dept Human & Mol Genet, Richmond, VA USA

[27] QIMR Berghofer Med Res Inst, Genet Epidemiol, Brisbane, Qld, Australia

[28] Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland

[29] Helsinki Univ Hosp, Helsinki, Finland

[30] Folkhalsan Res Ctr, Helsinki, Finland

[31] Agcy Sci Technol & Res, Singapore Inst Clin Sci, Singapore, Singapore

[32] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Obstet & Gynaecol, Singapore, Singapore

[33] Univ Tartu, Inst Genom, Estonian Genome Ctr, Tartu, Estonia

[34] Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA 02142 USA

[35] German Res Ctr Environm Hlth, Res Unit Mol Epidemiol, Helmholtz Zentrum Munchen, Inst Epidemiol, Neuherberg, Germany

[36] German Ctr Diabet Res DZD, Neuherberg, Germany

[37] Martin Luther Univ Halle Wittenberg, Univ Clin, Halle, Saale, Germany

[38] Martin Luther Univ Halle Wittenberg, Outpatient Clin Psychiat Psychotherapy & Psychoso, Halle, Saale, Germany

[39] Indiana Univ, Dept Epidemiol, Richard M Fairbanks Sch Publ Hlth, Indianapolis, IN 46204 USA

[40] Indiana Univ, Melvin & Bren Simon Canc Ctr, Indianapolis, IN 46204 USA

[41] Mental Hlth Serv Copenhagen, Inst Biol Psychiat, Copenhagen, Denmark

[42] Copenhagen Univ Hosp, Danish Headache Ctr, Glostrup, Denmark

[43] Univ Edinburgh, Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland

[44] Univ Helsinki, Inst Mol Med FIMM, Helsinki, Finland

[45] Eurac Res, Inst Biomed, Bolzano, Italy

[46] Boston Childrens Hosp, Div Endocrinol, Boston, MA USA

[47] Harvard Med Sch, Dept Genet, Boston, MA 02115 USA

[48] Broad Inst, Med & Populat Genet, Cambridge, MA USA

[49] Univ Med Ctr, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands

[50] Univ Helsinki, Dept Publ Hlth, Helsinki, Finland

来源：

NATURE HUMAN BEHAVIOUR | 2021年 / 5卷 / 01期

基金：

英国医学研究理事会; 澳大利亚国家健康与医学研究理事会; 英国惠康基金; 澳大利亚研究理事会; 芬兰科学院; 新加坡国家研究基金会;

关键词：

LANGUAGE DOMINANCE; LINKAGE ANALYSIS; METAANALYSIS; MICROTUBULE; ASYMMETRY; AUTISM; LATERALIZATION; SCHIZOPHRENIA; ORIGINS; SCREEN;

D O I：

10.1038/s41562-020-00956-y

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P < 5 x 10(-8)) with left-handedness and 7 associated with ambidexterity. Tissue-enrichment analysis implicated the CNS in the aetiology of handedness. Pathways including regulation of microtubules and brain morphology were also highlighted. We found suggestive positive genetic correlations between left-handedness and neuropsychiatric traits, including schizophrenia and bipolar disorder. Furthermore, the genetic correlation between left-handedness and ambidexterity is low (r(G) = 0.26), which implies that these traits are largely influenced by different genetic mechanisms. Our findings suggest that handedness is highly polygenic and that the genetic variants that predispose to left-handedness may underlie part of the association with some psychiatric disorders. A genome-wide association study of 1.7 million individuals identified 41 genetic variants associated with left-handedness and 7 associated with ambidexterity. The genetic correlation between the traits was low, thereby implying different aetiologies.

引用

页码：59 / 70

页数：14

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