Ligand-Accelerated Palladium(II)-Catalyzed Enantioselective Amination of C(sp2)-H Bonds

被引：20
作者：
Cheng, Xiu-Fen [1 ,2 ,3 ]
Fei, Fan [1 ,2 ]
Li, Yan [1 ,2 ]
Hou, Yi-Ming [1 ,2 ]
Zhou, Xin [1 ,2 ]
Wang, Xi-Sheng [1 ,2 ]
机构：
[1] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Anhui, Peoples R China
[2] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China
[3] Shandong Normal Univ, Coll Chem Chem Engn & Mat Sci, Collaborat Innovat Ctr Functionalized Probes Chem, Key Lab Mol & Nano Probes,Minist Educ,Shandong Pr, Jinan 250014, Peoples R China
来源：
ORGANIC LETTERS | 2020年 / 22卷 / 16期
基金：
美国国家科学基金会; 中国博士后科学基金;
关键词：
C-H AMINATION; NITROGEN-ATOM TRANSFER; INDOLE ALKALOIDS; CYTOTOXIC ACTIVITY; C(SP(3))-H BONDS; TERMINAL OLEFINS; SULFAMATE ESTERS; ACTIVATION; AMIDATION; DIRHODIUM(II);
D O I：
10.1021/acs.orglett.0c02216
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first example of the Pd(II)-catalyzed enantioselective amination of aryl C-H bonds is reported. The key to the successful realization of this asymmetric catalytic transformation was the identification of mono-N-protected alpha-amino-O-methylhydroxamic acid (MPAHA) ligands, which promote reactivity under mild conditions and control enantioselectivity. The counteranions in the solvent medium, hexafluoroacetylacetate and acetate, were also found to play key roles in stereocontrol and reactivity enhancement.
引用
收藏
页码：6394 / 6398
页数：5
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