Fetoscopic laser coagulation in 200 consecutive monochorionic pregnancies with twin-twin transfusion syndrome

Objectives. - To report preoperative data, surgical characteristics, complications and perinatal outcome of twin-twin transfusion syndrome (TTTS) managed with laser ablation surgery, to analyze predictors of neonatal survival and to compare the 100 most recent cases with the older 100. Materials and methods. - Observational cohort moncentric study of 200 cases of TITS consecutively treated with fetoscopic laser coagulation between January 2004 and December 2014. Results.- There were 49 stage I, 88 stage II, 55 stage III and eight stage IV. Median gestation at time of laser was 20.1 +/- 3.0 weeks' gestation (WG) whereas median gestation at delivery was 31.6 +/- 5.4 WG. Overall perinatal survival rate was 68.0% and 84.0% have one or more surviving twins. Preterm premature rupture of membranes occurred in 39 cases with and the median gestational age for this complication was 28.8 +/- 4.6 SA. Predictive factors to have at least one living birth were Quintero stage and gestational age at delivery. In the most recent period, there were significantly more TITS Quintero stage I treated with laser, more coagulation by the Solomon technique and a larger number of coagulated vessels. Conclusion. - The neonatal survival of TITS is improved by fetoscopic laser coagulation, preferely by using Solomon tecnhique. The use of active management of stage I is currently on research. (C) 2017 Elsevier Masson SAS. All rights reserved.