Myocardial Involvement in Patients With Osteogenesis Imperfecta

被引：7

作者：

Soma, Katsura

Abe, Hajime

Takeda, Norihiko ^{[1
]}

Shintani, Yukako ^{[2
]}

Takazawa, Yutaka ^{[2
]}

Kojima, Toshiya

Fujiu, Katsuhito

Semba, Hiroaki

Yamashita, Hiroshi

Hirata, Yasunobu

Fukayama, Masashi ^{[2
]}

Nagai, Ryozo

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Cardiovasc Med, Bunkyo Ku, Tokyo 1138658, Japan

[2] Univ Tokyo, Fac Med, Dept Pathol, Tokyo 1138658, Japan

来源：

INTERNATIONAL HEART JOURNAL | 2012年 / 53卷 / 01期

基金：

日本学术振兴会;

关键词：

Osteogenesis imperfecta; Type I collagen; Mitral valve regurgitation; Myocardial fibrosis; CARDIOVASCULAR-DISEASES;

D O I：

10.1536/ihj.53.75

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mitral and aortic valve regurgitation is commonly found in osteogenesis imperfecta (OI) patients, however, little is known about the myocardial involvement in this disorder. An 82-year-old man with OI developed heart failure and was admitted to our hospital. Echocardiogram revealed severe mitral regurgitation without left ventricular (LV) dilatation, but with LV wall thickening. Histological analysis exhibited interstitial fibrosis of the myocardium in addition to myxoid changes of the mitral leaflet. These findings suggest that OI patients may develop LV remodeling together with diastolic dysfunction. (Int Heart J 2012; 53: 75-77)

引用

页码：75 / 77

页数：3

共 8 条

[1]

Aoki Tadashi, 2002, Ann Thorac Cardiovasc Surg, V8, P51

[2] Valvular Heart Disease in Osteogenesis Imperfecta: Presentation of a Case and Review of the Literature [J].