Oncohistones: drivers of pediatric cancers

被引：79

作者：

Mohammad, Faizaan ^{[1
,2
]}

Helin, Kristian ^{[1
,2
]}

机构：

[1] Univ Copenhagen, BRIC, Fac Hlth Sci, DK-2200 Copenhagen, Denmark

[2] Univ Copenhagen, Novo Nordisk Ctr Stem Cell Biol Danstem, Fac Hlth Sci, DK-2200 Copenhagen, Denmark

来源：

GENES & DEVELOPMENT | 2017年 / 31卷 / 23-24期

基金：

欧洲研究理事会; 英国医学研究理事会; 新加坡国家研究基金会;

关键词：

cancer; chromatin; oncohistone; DIFFUSE INTRINSIC PONTINE; HISTONE VARIANT H3.3; HIGH-GRADE; GENOMIC LANDSCAPE; MOLECULAR-BASIS; MUTATIONS; CHROMATIN; METHYLATION; INHIBITION; GLIOMA;

D O I：

10.1101/gad.309013.117

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

One of the most striking results in the area of chromatin and cancer in recent years has been the identification of recurrent mutations in histone genes in pediatric cancers. These mutations occur at high frequency and lead to the expression of mutant histones that exhibit oncogenic features. Thus, they are termed oncohistones. Thus far, mutations have been found in the genes encoding histone H3 and its variants. The expression of the oncohistones affects the global chromatin landscape through mechanisms that have just begun to be unraveled. In this review, we provide an overview of histone mutations that have been identified and discuss the possible mechanisms by which they contribute to tumor development. We further discuss the targeted therapies that have been proposed to treat cancers expressing oncohistones.

引用

页码：2313 / 2324

页数：12

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