Intensifying the microencapsulation process: Ultrasonic atomization as an innovative approach

被引:86
作者
Dalmoro, Annalisa [1 ,2 ]
Barba, Anna Angela [1 ]
Lamberti, Gaetano [2 ]
d'Amore, Matteo [1 ]
机构
[1] Univ Salerno, Dipartimento Sci Farmaceut & Biomed, I-84084 Fisciano, SA, Italy
[2] Univ Salerno, Dipartimeno Ingn Ind, I-84084 Fisciano, SA, Italy
关键词
Microencapsulation; Process intensification; Atomization assisted by ultrasonic energy; Microparticles production; POLY(LACTIDE-CO-GLYCOLIDE) MICROSPHERES; SOLVENT EXTRACTION/EVAPORATION; MANUFACTURING PARAMETERS; PROCESS INTENSIFICATION; CONTROLLED-RELEASE; ENCAPSULATION; MICROPARTICLES; THEOPHYLLINE; PROFILES; ATOMIZER;
D O I
10.1016/j.ejpb.2012.01.006
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
In this review, new approaches to the microencapsulation processes, widely used in the manufacturing of pharmaceutical products, are discussed focusing the attention on the emerging ultrasonic atomization technique. Fundamentals and novel aspects are presented, and advantages of ultrasonic atomization in terms of intensification and low energy requests are emphasized. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码:471 / 477
页数:7
相关论文
共 60 条
[21]   Ultrasonic atomisation into reduced pressure atmosphere - envisaging aseptic spray-drying for microencapsulation [J].
Freitas, S ;
Merkle, HP ;
Gander, B .
JOURNAL OF CONTROLLED RELEASE, 2004, 95 (02) :185-195
[22]   Towards a methodology for the systematic analysis and design of efficient chemical processes Part 1. From unit operations to elementary process functions [J].
Freund, Hannsjoerg ;
Sundmacher, Kai .
CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION, 2008, 47 (12) :2051-2060
[23]   Improvement of the encapsulation efficiency of oligonucleotide-containing biodegradable microspheres [J].
Freytag, T ;
Dashevsky, A ;
Tillman, L ;
Hardee, GE ;
Bodmeier, R .
JOURNAL OF CONTROLLED RELEASE, 2000, 69 (01) :197-207
[24]   Ketoprofen-poly(D,L-lactic-co-glycolic acid) microspheres: influence of manufacturing parameters and type of polymer on the release characteristics [J].
Gabor, F ;
Ertl, B ;
Wirth, M ;
Mallinger, R .
JOURNAL OF MICROENCAPSULATION, 1999, 16 (01) :1-12
[25]   Microencapsulation: industrial appraisal of existing technologies and trends [J].
Gouin, S .
TRENDS IN FOOD SCIENCE & TECHNOLOGY, 2004, 15 (7-8) :330-347
[26]   Encapsulation of indomethacin using coaxial ultrasonic atomization followed by solvent evaporation [J].
Graves, Richard A. ;
Poole, Daniel ;
Moiseyev, Raisa ;
Bostanian, Levon A. ;
Mandal, Tarun K. .
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2008, 34 (04) :419-426
[27]   Comparison of the effects of different drying techniques on properties of granules and tablets made on a production scale [J].
Hegedus, Agota ;
Pintye-Hodi, Klara .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2007, 330 (1-2) :99-104
[28]   Process considerations related to the microencapsulation of plasmid DNA via ultrasonic atomization [J].
Ho, Jenny ;
Wang, Huanting ;
Forde, Gareth M. .
BIOTECHNOLOGY AND BIOENGINEERING, 2008, 101 (01) :172-181
[29]   Microencapsulation techniques, factors influencing encapsulation efficiency [J].
Jyothi, N. Venkata Naga ;
Prasanna, P. Muthu ;
Sakarkar, Suhas Narayan ;
Prabha, K. Surya ;
Ramaiah, P. Seetha ;
Srawan, G. Y. .
JOURNAL OF MICROENCAPSULATION, 2010, 27 (03) :187-197
[30]   Practical method for choosing diluent that ensures the best temperature uniformity in the case of pharmaceutical microwave vacuum drying of a heat sensitive product [J].
Kelen, A ;
Pallai-Varsanyi, E ;
Ress, S ;
Nagy, T ;
Pintye-Hodi, K .
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2006, 62 (01) :101-109