Obesity, autophagy and the pathogenesis of liver and pancreatic cancers

被引：37

作者：

Aghajan, Mariam

Li, Ning

Karin, Michael

机构：

[1] Univ Calif San Diego, Sch Med, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, San Diego, CA 92103 USA

[2] Univ Calif San Diego, Sch Med, Dept Pathol, Lab Gene Regulat & Signal Transduct, San Diego, CA 92103 USA

来源：

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 2012年 / 27卷

关键词：

autophagy; hepatocellular carcinoma; nuclear factor-kappa B; p62; pancreatic ductal adenocarcinoma; NF-KAPPA-B; HEPATOCELLULAR-CARCINOMA; DEFICIENT MICE; P62; TUMORIGENESIS; ACTIVATION; INFLAMMATION; STRESS; SENESCENCE; DISEASE;

D O I：

10.1111/j.1440-1746.2011.07008.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Liver and pancreatic cancers are both highly lethal diseases with limited to no therapeutic options for patients. Recent studies suggest that deregulated autophagy plays a role in the pathogenesis of these diseases by perturbing cellular homeostasis and laying the foundation for disease development. While accumulation of p62 upon impaired autophagy has been implicated in hepatocellular carcinoma, its role in pancreatic ductal adenocarcinoma remains less clear. This review will focus on recent studies illustrating the role of autophagy in liver and pancreatic cancers. The relationships between autophagy, nuclear factor-kappa B signaling and obesity in hepatocellular carcinoma will be discussed, as well as the dual role of autophagy in pancreatic ductal adenocarcinoma.

引用

页码：10 / 14

页数：5

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