Rifamycin Resistance in Clostridium difficile Is Generally Associated with a Low Fitness Burden

被引：17

作者：

Dang, Uyen T. ^{[1
]}

Zamora, Idalia ^{[1
]}

Hevener, Kirk E. ^{[2
]}

Adhikari, Sudip ^{[1
]}

Wu, Xiaoqian ^{[3
]}

Hurdle, Julian G. ^{[1
,3
,4
]}

机构：

[1] Univ Texas Arlington, Dept Biol, Arlington, TX 76019 USA

[2] Idaho State Univ, Coll Pharm, Biomed & Pharmaceut Sci, Meridian, ID USA

[3] Texas A&M Hlth Sci Ctr, Inst Biosci & Technol, Ctr Infect & Inflammatory Dis, Houston, TX 77030 USA

[4] Texas A&M Hlth Sci Ctr, Coll Med, Dept Microbial & Mol Pathogenesis, Bryan, TX 77807 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2016年 / 60卷 / 09期

关键词：

STAPHYLOCOCCUS-AUREUS; RNA-POLYMERASE; RIFAXIMIN; INFECTION; RIFAMPIN; METRONIDAZOLE; VANCOMYCIN; SELECTION; BACTERIA; DIARRHEA;

D O I：

10.1128/AAC.01137-16

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We characterized clinically occurring and novel mutations in the beta subunit of RNA polymerase in Clostridium difficile (CdRpoB), conferring rifamycin (including rifaximin) resistance. The Arg(505)Lys substitution did not impose an in vitro fitness cost, which may be one reason for its dominance among rifamycin-resistant clinical isolates. These observations were supported through the structural modeling of CdRpoB. In general, most mutations lacked in vitro fitness costs, suggesting that rifamycin resistance may in some cases persist in the clinic.

引用

页码：5604 / 5607

页数：4

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