Occupational exposure of dental technicians to methyl methacrylate: Genotoxicity assessment

被引：2

作者：

Soykut, Bugra ^{[1
]}

Erdem, Onur ^{[2
]}

Yalcin, Can Ozgur ^{[3
]}

Ustundag, Aylin ^{[4
]}

Duydu, Yalcin ^{[4
]}

Akay, Cemal ^{[1
]}

Piskin, Bulent ^{[5
]}

机构：

[1] Gulhane Mil Med Acad, Dept Pharmaceut Toxicol, TR-06010 Ankara, Turkey

[2] Univ Hlth Sci, Dept Pharmaceut Toxicol, Gulhane Fac Pharm, TR-06010 Ankara, Turkey

[3] Karadeniz Tech Univ, Dept Pharmaceut Toxicol, Fac Pharm, TR-61080 Trabzon, Turkey

[4] Ankara Univ, Dept Pharmaceut Toxicol, Fac Pharm, TR-06560 Ankara, Turkey

[5] Gulhane Mil Med Acad, Dept Prosthodont, TR-06010 Ankara, Turkey

来源：

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS | 2020年 / 852卷

关键词：

Buccal micronucleus; Methyl methacrylate; COMET assay; Adaptive response; Cytome assay; 8-OHdG; COMET ASSAY; NUCLEAR ANOMALIES; HUMAN-LYMPHOCYTES; PERIPHERAL-BLOOD; OXIDATIVE STRESS; BUCCAL MUCOSA; IN-VITRO; MICRONUCLEI; DAMAGE; TOXICOLOGY;

D O I：

10.1016/j.mrgentox.2020.503159

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Dental technicians may be chronically exposed to methyl methacrylate (MMA), used in the production of dental prostheses. We have studied whether occupational exposure to MMA affects genotoxicity biomarkers such as 8-OHdG formation, comet assay, and buccal micronucleus frequency. MMA exposure was assessed via ambient air analysis. Although no significant differences between exposed and non-exposed individuals were seen with respect to blood genotoxicity measurements, we found a higher level of buccal-cell anomalies in the exposed group.

引用

页数：5

共 39 条

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