Genomic Integration of HHV-6 Mimicking Viral Reactivation after Autologous Stem Cell Transplantation

被引：0

作者：

Mineri, Rossana ^{[1
]}

Mariotti, Jacopo ^{[2
]}

Sarina, Barbara ^{[2
]}

Morabito, Lucio ^{[2
]}

Crocchiolo, Roberto ^{[2
]}

Bramanti, Stefania ^{[2
]}

Sarno, Tiziana ^{[1
]}

Tordato, Federica ^{[3
]}

Carlo-Stella, Carmelo ^{[2
]}

Santoro, Armando ^{[2
,4
]}

Castagna, Luca ^{[2
]}

机构：

[1] Humanitas Clin & Res Ctr, Mol Biol Sect, Clin Invest Lab, Via Manzoni 56, I-20089 Rozzano, Italy

[2] Humanitas Clin & Res Ctr, Humanitas Canc Ctr, Hematol Unit, Via Manzoni 56, I-20089 Rozzano, Italy

[3] Humanitas Clin & Res Ctr, Infect Dis Unit, Via Manzoni 56, I-20089 Rozzano, Italy

[4] Humanitas Univ, Via Alessandro Manzoni 113, I-20089 Rozzano, Mi, Italy

来源：

MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES | 2018年 / 10卷

关键词：

Bone marrow transplantation; Infectious disease; HHV-6; integration; HUMAN HERPESVIRUS-6; HUMAN-HERPESVIRUS-6; RECIPIENTS; INFECTION; DNA; TRANSMISSION; DISEASE;

D O I：

10.4084/MJHID.2018.013

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The monitoring of Human Herpesvirus 6 (HHV-6) after allogeneic stem cell transplantation has proven to be useful in preventing life-threatening complications; however, the pathogenic role of HHV-6 after autologous transplantation is not well-characterized, although viral reactivation might be responsible for significant complications even after this type of transplant. Here we report, for the first time to our knowledge, the case of a patient with chromosomally integrated HHV-6 (ciHHV-6), presenting with high titers of HHV-6 DNA copies after autologous transplantation, mimicking HHV-6 reactivation. The presence of viral DNA in the follicle bulb confirmed the ciHHV-6 and allowed for the discontinuation of the antiviral treatment. Due to the increasing awareness of HHV-6 potential pathogenicity and the fact that ciHHV-6 is expected in 1-2% of the population, such a case might be helpful in recognizing ci HHV-6, thus avoiding unnecessary and potentially toxic antiviral therapy once the viral genomic integration is confirmed.

引用

页数：4

共 19 条

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