In vitro Degradation and biocompatibility of WE43, ZK60, and AZ91 Biodegradable Magnesium Alloys

被引：14

作者：

Liu, C. L. ^{[1
,2
]}

Jiang, J. ^{[2
]}

Wang, M. ^{[1
]}

Wang, Y. J. ^{[3
]}

Chu, Paul K. ^{[2
]}

Huang, W. J. ^{[1
]}

机构：

[1] Chongqing Inst Technol, Sch Mat Sci & Engn, Chongqing 400054, Peoples R China

[2] City Univ Hong Kong, Dept Phys & Mat Sci, Kowloon, Hong Kong, Peoples R China

[3] Chongqing Inst Technol, Sch Appl Sci & Technol, Chongqing 400054, Peoples R China

来源：

APPLICATIONS OF ENGINEERING MATERIALS, PTS 1-4 | 2011年 / 287-290卷

基金：

中国国家自然科学基金;

关键词：

Degradation; Cytotoxicity; Micronuclei; Magnesium alloy; Implant materials; CORROSION MECHANISMS; BEHAVIOR; CELLS; BONE;

D O I：

10.4028/www.scientific.net/AMR.287-290.2008

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Successful application of magnesium alloys as degradable load-bearing implants is determined by their biological performance especially degradation and corrosion behavior in the human body. Three magnesium alloys, namely WE43, ZK60, and AZ91 are investigated in this work. The in vitro degradation behavior, cytotoxicity, and genotoxicity are evaluated by corrosion tests, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and micronuclei tests, respectively. Immersion tests indicate that the ZK60 alloy has the best corrosion resistance and lowest corrosion rate in flank's solution, followed by AZ91 alloy and WE43 alloy in that order. The MTT results obtained from the three magnesium alloys after 7 days of immersion indicate good cellular viability. However, excessively high aluminum and magnesium concentrations have a negative influence on the genetic stability.

引用

页码：2008 / +

页数：2

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