PHF6: it is written in the stem cells

被引：6

作者：

Ntziachristos, Panagiotis ^{[1
]}

机构：

[1] Northwestern Univ, Evanston, IL 60208 USA

来源：

BLOOD | 2019年 / 133卷 / 23期

关键词：

MUTATIONS; LEUKEMIA;

D O I：

10.1182/blood.2019000810

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In the current issue of Blood, Miyagi et al investigated the role of the plant homeodomain-like finger protein 6 (PHF6) in hematopoietic stem cell (HSC) self-renewal in an attempt to further clarify the previously suggested tumor suppressive role of this protein in human leukemia. 1 Interestingly, Phf6 ablation rendered HSCs less responsive to inflammatory stress signals, but was able to increase HSCs proliferation rates, which might, at least in part, contribute to oncogenic transformation (see figure).

引用

页码：2461 / 2462

页数：2

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