A hormonal signaling pathway influencing C-elegans metabolism, reproductive development, and life span

被引：301

作者：

Gerisch, B ^{[1
]}

Weitzel, C ^{[1
]}

Kober-Eisermann, C ^{[1
]}

Rottiers, V ^{[1
]}

Antebi, A ^{[1
]}

机构：

[1] Max Planck Inst Mol Genet, D-14195 Berlin, Germany

来源：

DEVELOPMENTAL CELL | 2001年 / 1卷 / 06期

关键词：

D O I：

10.1016/S1534-5807(01)00085-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

During C. elegans development, animals must choose between reproductive growth or dauer diapause in response to sensory cues. Insulin/IGF-I and TGF-beta signaling converge on the orphan nuclear receptor daf-12 to mediate this choice. Here we show that daf-9 acts downstream of these inputs but upstream of daf-12. daf-9 and daf-12 mutants have similar larval defects and modulate insulin/IGF-I and gonadal signals that regulate adult life span. daf-9 encodes a cytochrome P450 related to vertebrate steroidogenic hydroxylases, suggesting that it could metabolize a DAF-12 ligand. Sterols may be the daf-9 substrate and daf-12 ligand because cholesterol deprivation phenocopies mutant defects. Sensory neurons, hypodermis, and somatic gonadal cells expressing daf-9 identify potential endocrine tissues. Evidently, lipophilic hormones influence nematode metabolism, diapause, and life span.

引用

页码：841 / 851

页数：11

共 61 条

[1] MUTANTS OF CAENORHABDITIS-ELEGANS THAT FORM DAUER-LIKE LARVAE [J].