Collective migration and cell jamming

被引:168
作者
Sadati, Monirosadat [1 ]
Qazvini, Nader Taheri [1 ,2 ]
Krishnan, Ramaswamy [3 ]
Park, Chan Young [1 ]
Fredberg, Jeffrey J. [1 ]
机构
[1] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA
[2] Univ Tehran, Coll Sci, Sch Chem, Tehran, Iran
[3] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA
基金
瑞士国家科学基金会;
关键词
Heterogeneity; Cooperativity; Kinetic arrest; Glass transition; DIFFERENTIAL ADHESION; DYNAMICS; MORPHOGENESIS; INVASION; BEHAVIOR;
D O I
10.1016/j.diff.2013.02.005
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Our traditional physical picture holds with the intuitive notion that each individual cell comprising the cellular collective senses signals or gradients and then mobilizes physical forces in response. Those forces, in turn, drive local cellular motions from which collective cellular migrations emerge. Although it does not account for spontaneous noisy fluctuations that can be quite large, the tacit assumption has been one of linear causality in which systematic local motions, on average, are the shadow of local forces, and these local forces are the shadow of the local signals. New lines of evidence now suggest a rather different physical picture in which dominant mechanical events may not be local, the cascade of mechanical causality may be not so linear, and, surprisingly, the fluctuations may not be noise as much as they are an essential feature of mechanism. Here we argue for a novel synthesis in which fluctuations and non-local cooperative events that typify the cellular collective might be illuminated by the unifying concept of cell jamming. jamming has the potential to pull together diverse factors that are already known to contribute but previously had been considered for the most part as acting separately and independently. These include cellular crowding, intercellular force transmission, cadherin-dependent cell-cell adhesion, integrin-dependent cell-substrate adhesion, myosin-dependent motile force and contractility, actin-dependent deformability, proliferation, compression and stretch. (c) 2013 International Society of Differentiation. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:121 / 125
页数:5
相关论文
共 42 条
  • [1] Glass-like dynamics of collective cell migration
    Angelini, Thomas E.
    Hannezo, Edouard
    Trepat, Xavier
    Marquez, Manuel
    Fredberg, Jeffrey J.
    Weitz, David A.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (12) : 4714 - 4719
  • [2] Cell Migration Driven by Cooperative Substrate Deformation Patterns
    Angelini, Thomas E.
    Hannezo, Edouard
    Trepat, Xavier
    Fredberg, Jeffrey J.
    Weitz, David A.
    [J]. PHYSICAL REVIEW LETTERS, 2010, 104 (16)
  • [3] Direct experimental evidence of a growing length scale accompanying the glass transition
    Berthier, L
    Biroli, G
    Bouchaud, JP
    Cipelletti, L
    El Masri, D
    L'Hôte, D
    Ladieu, F
    Pierno, M
    [J]. SCIENCE, 2005, 310 (5755) : 1797 - 1800
  • [4] Jamming by shear
    Bi, Dapeng
    Zhang, Jie
    Chakraborty, Bulbul
    Behringer, R. P.
    [J]. NATURE, 2011, 480 (7377) : 355 - 358
  • [5] D'Arcy Thompson W., 1942, On growth and form
  • [6] Integrin-dependent actomyosin contraction regulates epithelial cell scattering
    de Rooij, J
    Kerstens, A
    Danuser, G
    Schwartz, MA
    Waterman-Storer, CM
    [J]. JOURNAL OF CELL BIOLOGY, 2005, 171 (01) : 153 - 164
  • [7] Biomechanics: Cell Research and Applications for the Next Decade
    Discher, Dennis
    Dong, Cheng
    Fredberg, Jeffrey J.
    Guilak, Farshid
    Ingber, Donald
    Janmey, Paul
    Kamm, Roger D.
    Schmid-Schoenbein, Geert W.
    Weinbaum, Sheldon
    [J]. ANNALS OF BIOMEDICAL ENGINEERING, 2009, 37 (05) : 847 - 859
  • [8] Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia
    Eisenhoffer, George T.
    Loftus, Patrick D.
    Yoshigi, Masaaki
    Otsuna, Hideo
    Chien, Chi-Bin
    Morcos, Paul A.
    Rosenblatt, Jody
    [J]. NATURE, 2012, 484 (7395) : 546 - U183
  • [9] The differential adhesion hypothesis: a direct evaluation
    Foty, RA
    Steinberg, MS
    [J]. DEVELOPMENTAL BIOLOGY, 2005, 278 (01) : 255 - 263
  • [10] Collective cell migration in morphogenesis and cancer
    Friedl, P
    Hegerfeldt, Y
    Tusch, M
    [J]. INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 2004, 48 (5-6) : 441 - 449