Diazoniapolycyclic Ions Inhibit the Activity of Topoisomerase I and the Growth of Certain Tumor Cell Lines

被引：15
作者：
Basili, Serena [1 ]
Basso, Giuseppe [2 ]
Faccio, Anita [1 ]
Granzhan, Anton [3 ]
Ihmels, Heiko [3 ]
Moro, Stefano [1 ]
Viola, Giampietro [1 ,2 ]
机构：
[1] Univ Padua, Dept Pharmaceut Sci, I-35131 Padua, Italy
[2] Univ Padua, Dept Pediat, I-35131 Padua, Italy
[3] Univ Siegen, D-57068 Siegen, Germany
来源：
CHEMMEDCHEM | 2008年 / 3卷 / 11期
关键词：
cell toxicity; DNA intercalators; nitrogen heterocycles; topoisomerase;
D O I：
10.1002/cmdc.200800186
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Unsubstituted polyaromatic dications exhibit a significant influence on the activity of topoisomerase I, as shown by plasmid relaxation assays and molecular modeling studies. Moreover, these compounds inhibit the growth of selected human tumor cell lines. (Figure Presented). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：1671 / 1676
页数：6
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