Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19

被引：1321

作者：

Sekine, Takuya ^{[1
]}

Perez-Potti, Andre ^{[1
]}

Rivera-Ballesteros, Olga ^{[1
]}

Stralin, Kristoffer ^{[2
]}

Gorin, Jean-Baptiste ^{[1
]}

Olsson, Annika ^{[2
]}

Llewellyn-Lacey, Sian ^{[3
]}

Kamal, Habiba ^{[2
]}

Bogdanovic, Gordana ^{[4
,13
]}

Muschiol, Sandra ^{[4
,13
]}

Wullimann, David J. ^{[1
]}

Kammann, Tobias ^{[1
]}

Emgard, Johanna ^{[1
]}

Parrot, Tiphaine ^{[1
]}

Folkesson, Elin ^{[2
]}

Rooyackers, Olav ^{[5
,6
]}

Eriksson, Lars, I ^{[6
,7
]}

Henter, Jan-Inge ^{[8
,14
]}

Sonnerborg, Anders ^{[2
,9
]}

Allander, Tobias ^{[4
,9
,13
]}

Albert, Jan ^{[4
,9
,13
]}

Nielsen, Morten ^{[10
,11
]}

Klingstrom, Jonas ^{[1
]}

Gredmark-Russ, Sara ^{[1
,2
]}

Bjorkstrom, Niklas K. ^{[1
]}

Sandberg, Johan K. ^{[1
]}

Price, David A. ^{[3
,12
]}

Ljunggren, Hans-Gustaf ^{[1
]}

Aleman, Soo ^{[1
,2
]}

Buggert, Marcus ^{[1
]}

机构：

[1] Karolinska Inst, Ctr Infect Med, Dept Med Huddinge, Stockholm, Sweden

[2] Karolinska Univ Hosp, Karolinska Inst, Dept Med Huddinge, Div Infect Dis, Stockholm, Sweden

[3] Cardiff Univ, Univ Hosp Wales, Div Infect & Immun, Sch Med, Cardiff, Wales

[4] Karolinska Univ Hosp, Div Clin Microbiol, Stockholm, Sweden

[5] Karolinska Inst, Dept Clin Intervent & Technol, Stockholm, Sweden

[6] Karolinska Univ Hosp, Funct Perioperat Med & Intens Care, Stockholm, Sweden

[7] Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden

[8] Karolinska Inst, Dept Womens & Childrens Hlth, Childhood Canc Res Unit, Stockholm, Sweden

[9] Karolinska Inst, Dept Microbiol, Tumor & Cell Biol, Stockholm, Sweden

[10] Tech Univ Denmark, Dept Hlth Technol, Lyngby, Denmark

[11] Univ Nacl San Martin, Inst Invest Biotecnol, San Martin, Argentina

[12] Cardiff Univ, Univ Hosp Wales, Syst Immun Res Inst, Sch Med, Cardiff, Wales

[13] Karolinska Inst, Dept Lab Med, Stockholm, Sweden

[14] Karolinska Univ Hosp, Theme Childrens & Womens Hlth, Stockholm, Sweden

来源：

CELL | 2020年 / 183卷 / 01期

基金：

瑞典研究理事会; 英国惠康基金;

关键词：

ACUTE RESPIRATORY SYNDROME; RESPONSES; CORONAVIRUS; PROTECTION; ANTIGEN; EFFECTOR; AVIDITY;

D O I：

10.1016/j.cell.2020.08.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. Here, we systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute or convalescent COVID-19. Acute-phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic phenotype that correlated with various clinical markers of disease severity, whereas convalescent-phase SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotype. Importantly, SARS-CoV-2-specific T cells were detectable in antibody-seronegative exposed family members and convalescent individuals with a history of asymptomatic and mild COVID-19. Our collective dataset shows that SARS-CoV-2 elicits broadly directed and functionally replete memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19.

引用

页码：158 / +

页数：25

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