Ocular motor signatures of cognitive dysfunction in multiple sclerosis

被引：24
作者：
Fielding, Joanne [1 ,2 ,6 ]
Clough, Meaghan [1 ,2 ]
Beh, Shin [4 ,5 ]
Millist, Lynette [6 ]
Sears, Derek [4 ,5 ]
Frohman, Ashley N. [4 ,5 ]
Lizak, Nathaniel [3 ]
Lim, Jayne [6 ]
Kolbe, Scott [7 ]
Rennaker, Robert L., II [8 ]
Frohman, Teresa C. [4 ,5 ]
White, Owen B. [6 ]
Frohman, Elliot M. [4 ,5 ,8 ]
机构：
[1] Monash Univ, Sch Psychol Sci, Clayton, Vic 3800, Australia
[2] Monash Univ, Monash Inst Cognit & Clin Neurosci, Clayton, Vic 3800, Australia
[3] Monash Univ, Monash Med Sch, Clayton, Vic 3800, Australia
[4] Univ Texas Southwestern Sch Med, Dept Neurol, Dallas, TX 75390 USA
[5] Univ Texas Southwestern Sch Med, Dept Neurotherapeut, Dallas, TX 75390 USA
[6] Univ Melbourne, Royal Melbourne Hosp, Melbourne Brain Ctr, Dept Med, Parkville, Vic 3050, Australia
[7] Univ Melbourne, Dept Anat & Neurosci, Melbourne, Vic 3010, Australia
[8] Univ Texas Dallas, Dept Bioengn & Comp Sci, Richardson, TX 75080 USA
来源：
NATURE REVIEWS NEUROLOGY | 2015年 / 11卷 / 11期
关键词：
CLINICALLY ISOLATED SYNDROME; PREFRONTAL CORTEX; EYE-MOVEMENTS; CORTICAL ACTIVATION; INHIBITORY CONTROL; WORKING-MEMORY; EARLY-STAGE; IMPAIRMENT; SACCADES; PATHOLOGY;
D O I：
10.1038/nrneurol.2015.174
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The anatomical and functional overlap between ocular motor command circuitry and the higher-order networks that form the scaffolding for cognition makes for a compelling hypothesis that measures of ocular motility could provide a means to sensitively interrogate cognitive dysfunction in people with multiple sclerosis (MS). Such an approach may ultimately provide objective and reproducible measures of cognitive dysfunction that offer an innovative capability to refine diagnosis, improve prognostication, and more accurately codify disease burden. A further dividend may be the validation and application of biomarkers that can be used in studies aimed at identifying and monitoring preventative, protective and even restorative properties of novel neurotherapeutics in MS. This Review discusses the utility of ocular motor measures in patients with MS to characterize disruption to wide-ranging networks that support cognitive function.
引用
收藏
页码：637 / 645
页数：9
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