From structure to function: New insights into hepatitis C virus RNA replication

被引:155
作者
Appel, N
Schaller, T
Penin, F
Bartenschlager, R
机构
[1] Heidelberg Univ, Dept Mol Virol, D-69120 Heidelberg, Germany
[2] Univ Lyon 1, IFR BioSci Lyon Gerland 128, Inst Biol & Chim Prot, CNRS,UMR 5086, F-69367 Lyon, France
关键词
D O I
10.1074/jbc.R500026200
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:9833 / 9836
页数:4
相关论文
共 63 条
[31]   Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line [J].
Lohmann, V ;
Körner, F ;
Koch, JO ;
Herian, U ;
Theilmann, L ;
Bartenschlager, R .
SCIENCE, 1999, 285 (5424) :110-113
[32]   The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site [J].
Love, RA ;
Parge, HE ;
Wickersham, JA ;
Hostomsky, Z ;
Habuka, N ;
Moomaw, EW ;
Adachi, T ;
Hostomska, Z .
CELL, 1996, 87 (02) :331-342
[33]   Topology of the membrane-associated hepatitis C virus protein NS4B [J].
Lundin, M ;
Monné, M ;
Widell, A ;
von Heijne, G ;
Persson, MAA .
JOURNAL OF VIROLOGY, 2003, 77 (09) :5428-5438
[34]   Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus [J].
Meylan, E ;
Curran, J ;
Hofmann, K ;
Moradpour, D ;
Binder, M ;
Bartenschlager, R ;
Tschopp, R .
NATURE, 2005, 437 (7062) :1167-1172
[35]   Membrane association of the RNA-dependent RNA polymerase is essential for hepatitis C virus RNA replication [J].
Moradpour, D ;
Brass, V ;
Bieck, E ;
Friebe, P ;
Gosert, R ;
Blum, HE ;
Bartenschlager, R ;
Penin, F ;
Lohmann, V .
JOURNAL OF VIROLOGY, 2004, 78 (23) :13278-13284
[36]   Insertion of green fluorescent protein into nonstructural protein 5A allows direct visualization of functional hepatitis C virus replication complexes [J].
Moradpour, D ;
Evans, MJ ;
Gosert, R ;
Yuan, ZH ;
Blum, HE ;
Goff, SP ;
Lindenbach, BD ;
Rice, CM .
JOURNAL OF VIROLOGY, 2004, 78 (14) :7400-7409
[37]   Reduction of hepatitis C virus NS5A hyperphosphorylation by selective inhibition of cellular kinases activates viral RNA replication in cell culture [J].
Neddermann, P ;
Quintavalle, M ;
Di Pietro, C ;
Clementi, A ;
Cerretani, M ;
Altamura, S ;
Bartholomew, L ;
De Francesco, R .
JOURNAL OF VIROLOGY, 2004, 78 (23) :13306-13314
[38]   The hepatitis C viral NS3 protein is a processive DNA helicase with cofactor enhanced RNA unwinding [J].
Pang, PS ;
Jankowsky, E ;
Planet, PJ ;
Pyle, AM .
EMBO JOURNAL, 2002, 21 (05) :1168-1176
[39]   Structure and function of the membrane anchor domain of hepatitis C virus nonstructural protein 5A [J].
Penin, F ;
Brass, V ;
Appel, N ;
Ramboarina, S ;
Montserret, R ;
Ficheux, D ;
Blum, HE ;
Bartenschlager, R ;
Moradpour, D .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (39) :40835-40843
[40]   Structural biology of hepatitis C virus [J].
Penin, F ;
Dubuisson, J ;
Rey, FA ;
Moradpour, D ;
Pawlotsky, JM .
HEPATOLOGY, 2004, 39 (01) :5-19