Enantioselective Morita-Baylis-Hillman Reaction Organocatalyzed by Glucose-based Phosphinothiourea

被引：19
作者：
Yang Weihong
Sha Feng
Zhang Xin
Yuan Kui
Wu Xinyan [1 ]
机构：
[1] E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China
来源：
CHINESE JOURNAL OF CHEMISTRY | 2012年 / 30卷 / 11期
基金：
中国国家自然科学基金;
关键词：
asymmetric organocatalysis; Morita-Baylis-Hillman reaction; bifunctional phosphine; chiral phosphinothiourea; acrylate; THIOUREA CATALYSTS; MICHAEL ADDITION; PHOSPHINE ORGANOCATALYSTS; AROMATIC-ALDEHYDES; ADDUCTS; SACCHARIDES; KETONES; ROUTE;
D O I：
10.1002/cjoc.201200740
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A class of bifunctional phosphinothioureas derived from saccharide was developed as new organocatalysts for the enantioselective Morita-Baylis-Hillman reaction between acrylates and aldehydes. With 10 mol% of glucose-based phosphinothiourea 1d, the allylic alcohols were obtained in up to 96% yield and 83% ee under mild reaction conditions.
引用
收藏
页码：2652 / 2656
页数：5
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