Pathogenesis of subacute cutaneous lupus erythematosus

被引：27

作者：

Stavropoulos, P. G. ^{[1
]}

Goules, A. V. ^{[1
]}

Avgerinou, G. ^{[1
]}

Katsambas, A. D. ^{[1
]}

机构：

[1] Univ Athens, Sch Med, Dept Dermatol 1, A Syngros Hosp, Athens 16121, Greece

来源：

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY | 2008年 / 22卷 / 11期

关键词：

antibody-dependent cell-mediated cytotoxicity; apoptosis; pathogenesis; plasmacytoid dendritic cells; subacute cutaneous lupus erythematosus; type IIFNs;

D O I：

10.1111/j.1468-3083.2008.02806.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Subacute cutaneous lupus erythematosus (SCLE) is a photosensitive form of lupus-specific skin lesion that is strongly associated with the presence of anti-Ro/SSA autoantibody. The pathogenesis of SCLE includes genetic, environmental and immunologic factors. Recent studies provide strong evidence for the involvement of innate and cell-mediated immunity, underlying the important role of plasmacytoid dendritic cells, interferon-alpha and antibody-dependent cell cytotoxicity. In addition, a variety of cytokines, chemokines and adhesion molecules have been found to participate in the expansion phase of the autoimmune effector mechanisms. This article summarizes the recent immunological findings and reviews the current mechanisms which are implied in the development of the disease.

引用

页码：1281 / 1289

页数：9

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