Uniparental Markers in Italy Reveal a Sex-Biased Genetic Structure and Different Historical Strata

被引：63

作者：

Boattini, Alessio ^{[1
]}

Martinez-Cruz, Begona ^{[2
]}

Sarno, Stefania ^{[1
]}

Harmant, Christine ^{[3
,4
]}

Useli, Antonella ^{[5
]}

Sanz, Paula ^{[2
]}

Yang-Yao, Daniele ^{[1
]}

Manry, Jeremy ^{[3
,4
]}

Ciani, Graziella ^{[1
]}

Luiselli, Donata ^{[1
]}

Quintana-Murci, Lluis ^{[3
,4
]}

Comas, David ^{[2
]}

Pettener, Davide ^{[1
]}

机构：

[1] Univ Bologna, Dipartimento Sci Biol Geol & Ambientali, Lab Antropol Mol, Bologna, Italy

[2] Univ Pompeu Fabra, Dept Ciencies Salut & Vida, Inst Biol Evolut CSIC UPF, Barcelona, Spain

[3] Inst Pasteur, Human Evolutionary Genet Unit, Dept Genomes & Genet, Paris, France

[4] CNRS, Paris, France

[5] Univ Sassari, Dipartimento Sci Nat & Terr, I-07100 Sassari, Italy

来源：

PLOS ONE | 2013年 / 8卷 / 05期

关键词：

DNA; EUROPE; MTDNA; VARIABILITY; RESOLUTION; PATTERNS; PHYLOGEOGRAPHY; COLONIZATION; DIVERGENCE; DIVERSITY;

D O I：

10.1371/journal.pone.0065441

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Located in the center of the Mediterranean landscape and with an extensive coastal line, the territory of what is today Italy has played an important role in the history of human settlements and movements of Southern Europe and the Mediterranean Basin. Populated since Paleolithic times, the complexity of human movements during the Neolithic, the Metal Ages and the most recent history of the two last millennia (involving the overlapping of different cultural and demic strata) has shaped the pattern of the modern Italian genetic structure. With the aim of disentangling this pattern and understanding which processes more importantly shaped the distribution of diversity, we have analyzed the uniparentally-inherited markers in similar to 900 individuals from an extensive sampling across the Italian peninsula, Sardinia and Sicily. Spatial PCAs and DAPCs revealed a sex-biased pattern indicating different demographic histories for males and females. Besides the genetic outlier position of Sardinians, a North West-South East Y-chromosome structure is found in continental Italy. Such structure is in agreement with recent archeological syntheses indicating two independent and parallel processes of Neolithisation. In addition, date estimates pinpoint the importance of the cultural and demographic events during the late Neolithic and Metal Ages. On the other hand, mitochondrial diversity is distributed more homogeneously in agreement with older population events that might be related to the presence of an Italian Refugium during the last glacial period in Europe.

引用

页数：12

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