Recent Advances in Dual Temperature Responsive Block Copolymers and Their Potential as Biomedical Applications

被引：101

作者：

Kotsuchibashi, Yohei ^{[1
,2
]}

Ebara, Mitsuhiro ^{[2
,3
,4
]}

Aoyagi, Takao ^{[5
]}

Narain, Ravin ^{[6
]}

机构：

[1] Shizuoka Inst Sci & Technol, Dept Mat & Life Sci, 2200-2 Toyosawa, Shizuoka 4378555, Japan

[2] Natl Inst Mat Sci, Int Ctr Mat Nanoarchitecton WPI MANA, 1-1 Namiki, Tsukuba, Ibaraki 3050044, Japan

[3] Tokyo Univ Sci, Grad Sch Ind Sci & Technol, 6-3-1 Niijuku, Tokyo 1258585, Japan

[4] Univ Tsukuba, Grad Sch Pure & Appl Sci, Dept Mat Engn, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058577, Japan

[5] Nihon Univ, Coll Sci & Technol, Chiyoda Ku, 1-8-14 Kanda Surugadai, Tokyo 1018308, Japan

[6] Univ Alberta, Dept Chem & Mat Engn, Edmonton, AB T6G 2G6, Canada

来源：

POLYMERS | 2016年 / 8卷 / 11期

基金：

加拿大自然科学与工程研究理事会;

关键词：

dual thermoresponsive block copolymers; smart polymers; biomaterials; THERMOSENSITIVE DIBLOCK COPOLYMERS; LIVING CATIONIC-POLYMERIZATION; FRAGMENTATION CHAIN TRANSFER; FREE-RADICAL POLYMERIZATION; ABA TRIBLOCK COPOLYMERS; SILICA NANOPARTICLES; RAFT POLYMERIZATION; CLICK CHEMISTRY; DRUG-DELIVERY; VINYL ETHERS;

D O I：

10.3390/polym8110380

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The development of stimuli responsive polymers has progressed significantly with novel preparation techniques, which has allowed access to new materials with unique properties. Dual thermoresponsive (double temperature responsive) block copolymers are particularly of interest as their properties can change depending on the lower critical solution temperature (LCST) or upper critical solution temperature (UCST) of each segment. For instance, these block copolymers can change from being hydrophilic, to amphiphilic or to hydrophobic simply by changing the solution temperature without any additional chemicals and the block copolymers can change from being fully solubilized to self-assembled structures to macroscopic aggregation/precipitation. Based on the unique solution properties, these dual thermo-responsive block copolymers are expected to be suitable for biomedical applications. This review is divided into three parts; LCST-LCST types of block copolymers, UCST-LCST types of block copolymers, and their potential as biomedical applications.

引用

页数：25

共 134 条

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