Production of nanoparticles-in-microparticles by a double emulsion method: A comprehensive study

被引：41
作者：
Lee, Yan-Sim [1 ]
Johnson, Philip J. [2 ]
Robbins, Philip T. [1 ]
Bridson, Rachel H. [1 ]
机构：
[1] Univ Birmingham, Sch Chem Engn, Birmingham B15 2TT, W Midlands, England
[2] Univ Birmingham, Sch Canc Studies, Birmingham B15 2TT, W Midlands, England
来源：
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | 2013年 / 83卷 / 02期
基金：
英国工程与自然科学研究理事会;
关键词：
Nanoparticles-in-microparticles; Solid-in-water-in-oil-water emulsion; Drug delivery; PLGA; PCL; Solvent evaporation; AEROSOL DELIVERY; FORMULATION; MICROSPHERES; ENCAPSULATION; OPTIMIZATION; SYSTEM; DRUGS;
D O I：
10.1016/j.ejpb.2012.10.016
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A method based on a double emulsion system (solid-in-water-in-oil-in-water) has been developed for the production of nanoparticles-in-microparticles (NIMs). The distribution of nanoparticles within the NIMs was explored using light and electron microscopy and through assessment of drug loading and release profiles. The extent of nanoparticle entrapment within the NIMs was found to be dependent on the state (wet vs. dry) in which the nanoparticles were introduced to the formulation. The technique was readily adaptable to produce NIMs of different morphologies. It isproposed that NIMs and this method to produce them have broad application in drug delivery research. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：168 / 173
页数：6
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