Andropause: A review of the definition and treatment

被引：11
作者：
Samaras, N. [1 ]
Frangos, E. [2 ]
Forster, A. [1 ]
Lang, P. -O. [3 ,4 ]
Samaras, D. [5 ]
机构：
[1] Univ Hosp Geneva, Dept Internal Med Rehabil & Geriatr, CH-1226 Thonex, Switzerland
[2] Clin Jolimont, CH-1211 Geneva, Switzerland
[3] Clin Genolier, Nescens Ctr Prevent Med, Genolier, Switzerland
[4] Cranfield Univ, Translat Med Res Grp, Cranfield MK43 0AL, Beds, England
[5] Univ Hosp Geneva, Dept Med Specialties, CH-1211 Geneva, Switzerland
来源：
EUROPEAN GERIATRIC MEDICINE | 2012年 / 3卷 / 06期
关键词：
Andropause; Treatment; Hormones; Elderly; TESTOSTERONE-REPLACEMENT THERAPY; HORMONE-BINDING GLOBULIN; CORONARY-ARTERY-DISEASE; PITUITARY-TESTICULAR AXIS; ENDOGENOUS SEX-HORMONES; LOW SERUM TESTOSTERONE; AGE-RELATED-CHANGES; OLDER MEN; PROSTATE-CANCER; ANDROGEN DEFICIENCY;
D O I：
10.1016/j.eurger.2012.08.007
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Testosterone levels' decrease with age is well documented. It is related to abnormalities in the hypothalamic-pituitary-testicular axis, an age-related decline of Leydig cells mass and function, but also to lifestyle factors such as obesity, physical activity, smoking and alcohol. Despite the relation between low testosterone and several age-related disorders it is rarely looked for in older individuals. In this article, we review data on the definition and treatment modalities of andropause. We also look into the potential relation between testosterone replacement therapy and complications such as polycythemia, cardiovascular and prostate cancer. We finally present protocols of pretreatment evaluation and follow-up and argue the benefits and risks of testosterone treatment in this age group. (c) 2012 Elsevier Masson SAS and European Union Geriatric Medicine Society. All rights reserved.
引用
收藏
页码：368 / 373
页数：6
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