Investigation of the IL-1β+3954 C>T polymorphism and the risk of sepsis A case-control study

被引：1

作者：

Fu, Peng ^{[1
]}

Xie, Shouxiang ^{[2
]}

Zhang, Xiangcheng ^{[1
]}

机构：

[1] Nanjing Med Univ, Affiliated Huaian 1 Peoples Hosp, Dept Intens Care Unit, Huaian, Jiangsu, Peoples R China

[2] Nanjing Med Univ, Affiliated Huaian 1 Peoples Hosp, Dept Emergency, Huaian, Jiangsu, Peoples R China

来源：

MEDICINE | 2020年 / 99卷 / 31期

关键词：

+3954 C > T polymorphism; case-control study; IL-1; beta; sepsis; GENE POLYMORPHISMS; SEPTIC SHOCK; INTERLEUKIN-1; SUSCEPTIBILITY; VARIANTS; DISEASE; FAMILY; TNF;

D O I：

10.1097/MD.0000000000021022

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Studies have obtained conflicting findings regarding the association between the interleukin-1 beta (IL-1 beta) +3954 C>T polymorphism and the risk of sepsis. To evaluate the association between the IL-1 beta +3954 C>T polymorphism and sepsis risk in Chinese individuals, we conducted a study of 254 sepsis patients and 322 controls. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used for genotyping. We found that the IL-1 beta +3954 C>T polymorphism was associated with a reduced risk of sepsis. Subgroup analyses revealed that this significant association was more evident among nonsmokers, nondrinkers, individuals with body mass index <25, and individuals aged >= 60 years. The IL-1 beta +3954 C>T polymorphism was also associated with the 28-day mortality rate and severity of sepsis. In summary, the IL-1 beta +3954 C>T polymorphism confers a reduced risk of sepsis in Han Chinese. This polymorphism may serve as a marker that predicts patients' susceptibility to sepsis.

引用

页数：5

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Investigation of the IL-1β+3954 C&gt;T polymorphism and the risk of sepsis A case-control study

Investigation of the IL-1β+3954 C>T polymorphism and the risk of sepsis A case-control study