NLRC5: a key regulator of MHC class I-dependent immune responses

被引：290

作者：

Kobayashi, Koichi S. ^{[1
,3
,5
]}

van den Elsen, Peter J. ^{[2
,4
]}

机构：

[1] Texas A&M Hlth Sci Ctr, Coll Med, Dept Microbial & Mol Pathogenesis, College Stn, TX 77843 USA

[2] Vrije Univ Amsterdam, Med Ctr, Dept Pathol, Amsterdam, Netherlands

[3] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02215 USA

[4] Leiden Univ, Med Ctr, Dept Immunohematol & Blood Transfus, NL-2333 NA Leiden, Netherlands

[5] Harvard Univ, Sch Med, Dept Microbiol & Immunobiol, Boston, MA 02215 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2012年 / 12卷 / 12期

基金：

美国国家卫生研究院;

关键词：

BARE-LYMPHOCYTE-SYNDROME; COMPLEX CLASS-II; NUCLEOTIDE-BINDING DOMAIN; FAMILY-MEMBER NLRC5; NF-KAPPA-B; TRANSACTIVATOR CIITA; GENE-EXPRESSION; MICE LACKING; IFN-GAMMA; TRANSCRIPTIONAL COACTIVATOR;

D O I：

10.1038/nri3339

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The expression of MHC class I molecules is crucial for the initiation and regulation of adaptive immune responses against pathogens. NOD-, LRR- and CARD-containing 5 (NLRC5) was recently identified as a specific transactivator of MHC class I genes (CITA). NLRC5 and the master regulator for MHC class II genes, class II transactivator (CIITA), interact with similar MHC promoter-bound factors. Here, we provide a broad overview of the molecular mechanisms behind MHC class I transcription and the role of the class I transactivator NLRC5 in MHC class I-dependent immune responses.

引用

页码：813 / 820

页数：8

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