Two Cases of Hepatocellular Carcinoma Arising Over 20 Years after a Sustained Virologic Response Following Interferon Therapy for Chronic Hepatitis C

被引：0

作者：

Takata, Kazuhide ^{[1
]}

Ishii, Fuminori ^{[2
]}

Uchida, Yotaro ^{[1
]}

Fukuda, Hiromi ^{[1
]}

Yamauchi, Ryo ^{[1
]}

Umeda, Kaoru ^{[1
]}

Tsuchiya, Naoaki ^{[1
]}

Tanaka, Takashi ^{[1
]}

Yokoyama, Keiji ^{[1
]}

Morihara, Daisuke ^{[1
]}

Takeyama, Yasuaki ^{[1
]}

Shakado, Satoshi ^{[1
]}

Sakisaka, Shotaro ^{[1
]}

Hirai, Fumihito ^{[1
]}

机构：

[1] Fukuoka Univ, Dept Gastroenterol & Med, Fac Med, Fukuoka, Japan

[2] Fukuoka Univ, Dept Gastroenterol Surg, Fac Med, Fukuoka, Japan

来源：

INTERNAL MEDICINE | 2020年 / 59卷 / 15期

关键词：

hepatocellular carcinoma; interferon therapy; sustained virologic response; RECURRENCE; RISK;

D O I：

10.2169/internalmedicine.4479-20

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The development of hepatocellular carcinoma (HCC) after a sustained virologic response (SVR) due to interferon (IFN) therapy for hepatitis C virus infection remains a serious problem. We herein report 2 cases of HCC that developed more than 20 years after SVR with IFN therapy for chronic hepatitis C. The patients were 89- and 72-year-old men with HCC that developed 24-25 years after an SVR with IFN therapy. These patients regularly underwent imaging examinations; therefore, the HCC was detected in the early stage, when it was still curable. Both cases suggest that long-term surveillance after an SVR is effective for the detection of HCC, and radical treatment is possible.

引用

页码：1855 / 1860

页数：6

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