A Systems Approach and Skeletal Myogenesis

被引：7
作者：
Ito, Yoshiaki [1 ,2 ]
Kayama, Tomohiro [1 ,3 ]
Asahara, Hiroshi [1 ,2 ]
机构：
[1] Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Syst BioMed, Tokyo 1138510, Japan
[2] Natl Res Inst Child Hlth & Dev, Dept Syst BioMed, Tokyo 1578535, Japan
[3] Jikei Univ, Sch Med, Dept Orthoped Surg, Tokyo 1058461, Japan
来源：
COMPARATIVE AND FUNCTIONAL GENOMICS | 2012年
关键词：
EMBRYONIC STEM-CELLS; GENE-EXPRESSION; MUSCLE-CELLS; ID PROTEINS; DIFFERENTIATION; MYOD; EMAGE; REPRESSOR; DATABASE; TRANSCRIPTION;
D O I：
10.1155/2012/759407
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Skeletal myogenesis depends on the strict regulation of the expression of various gene subsets. Therefore, the understanding of genome wide gene regulation is imperative for elucidation of skeletal myogenesis. In recent years, systems approach has contributed to the understanding of various biological processes. Our group recently revealed the critical genome network of skeletal myogenesis by using a novel systems approach combined with whole-mount in situ hybridization ( WISH) database, high-throughput screening, and microarray analysis. In this paper, we introduce our systems approach for understanding the myogenesis regulatory network and describe the advantages of systems approach.
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页数：7
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共 42 条
  • [1] RP58 associates with condensed chromatin and mediates a sequence-specific transcriptional repression
    Aoki, K
    Meng, GY
    Suzuki, K
    Takashi, T
    Kameoka, Y
    Nakahara, K
    Ishida, R
    Kasai, M
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (41) : 26698 - 26704
  • [2] Genome-wide remodeling of the epigenetic landscape during myogenic differentiation
    Asp, Patrik
    Blum, Roy
    Vethantham, Vasupradha
    Parisi, Fabio
    Micsinai, Mariann
    Cheng, Jemmie
    Bowman, Christopher
    Kluger, Yuval
    Dynlacht, Brian David
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (22) : E149 - E158
  • [3] EMAP and EMAGE - A framework for understanding spatially organized data
    Baldock, RA
    Bard, JBL
    Burger, A
    Burton, N
    Christiansen, J
    Feng, GJ
    Hill, B
    Houghton, D
    Kaufman, M
    Rao, JG
    Sharpe, J
    Ross, A
    Stevenson, P
    Venkataraman, S
    Waterhouse, A
    Yang, Y
    Davidson, DR
    [J]. NEUROINFORMATICS, 2003, 1 (04) : 309 - 325
  • [4] THE PROTEIN ID - A NEGATIVE REGULATOR OF HELIX-LOOP-HELIX DNA-BINDING PROTEINS
    BENEZRA, R
    DAVIS, RL
    LOCKSHON, D
    TURNER, DL
    WEINTRAUB, H
    [J]. CELL, 1990, 61 (01) : 49 - 59
  • [5] MyoD and the transcriptional control of myogenesis
    Berkes, CA
    Tapscott, SJ
    [J]. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2005, 16 (4-5) : 585 - 595
  • [6] A bivalent chromatin structure marks key developmental genes in embryonic stem cells
    Bernstein, BE
    Mikkelsen, TS
    Xie, XH
    Kamal, M
    Huebert, DJ
    Cuff, J
    Fry, B
    Meissner, A
    Wernig, M
    Plath, K
    Jaenisch, R
    Wagschal, A
    Feil, R
    Schreiber, SL
    Lander, ES
    [J]. CELL, 2006, 125 (02) : 315 - 326
  • [7] An initial blueprint for myogenic differentiation
    Blais, A
    Tsikitis, M
    Acosta-Alvear, D
    Sharan, R
    Kluger, Y
    Dynlacht, BD
    [J]. GENES & DEVELOPMENT, 2005, 19 (05) : 553 - 569
  • [8] Reference Maps of Human ES and iPS Cell Variation Enable High-Throughput Characterization of Pluripotent Cell Lines
    Bock, Christoph
    Kiskinis, Evangelos
    Verstappen, Griet
    Gu, Hongcang
    Boulting, Gabriella
    Smith, Zachary D.
    Ziller, Michael
    Croft, Gist F.
    Amoroso, Mackenzie W.
    Oakley, Derek H.
    Gnirke, Andreas
    Eggan, Kevin
    Meissner, Alexander
    [J]. CELL, 2011, 144 (03) : 439 - 452
  • [9] The role of Pax genes in the development of tissues and organs:: Pax3 and Pax7 regulate muscle progenitor cell functions
    Buckingham, Margaret
    Relaix, Frederic
    [J]. ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2007, 23 : 645 - 673
  • [10] RNA sequence analysis defines Dicer's role in mouse embryonic stem cells
    Calabrese, J. Mauro
    Seila, Amy C.
    Yeo, Gene W.
    Sharp, Phillip A.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (46) : 18097 - 18102
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