Chronic Disseminated Salmonellosis in a Patient With Interleukin-12p40 Deficiency

被引：5

作者：

Alaki, Emadia Mohammad ^{[1
]}

Aljobair, Fahad ^{[2
]}

Alaklobi, Faisal ^{[2
]}

Al Shamrani, Mobarak ^{[2
]}

Al-Zahim, Fahad ^{[3
]}

Dongues, Aziza ^{[4
]}

Casanova, Jean-Laurent ^{[5
]}

机构：

[1] King Saud Med City, Pediat Allergy & Immunol Unit, Riyadh, Saudi Arabia

[2] King Saud Med City, Pediat Infect Dis Unit, Riyadh, Saudi Arabia

[3] King Saud Med City, Gen Pediat Dept, Riyadh, Saudi Arabia

[4] King Saud Med City, Pediat Epidemiol Dept, Riyadh, Saudi Arabia

[5] Rockefeller Univ, Lab Human Genet Infect Dis, 1230 York Ave, New York, NY 10021 USA

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2018年 / 37卷 / 01期

关键词：

interleukin-12p40; deficiency; chronic Salmonella; Bacille Calmette-Guerin (BCGitis); INTERFERON-GAMMA; DEFECTS; DISEASE;

D O I：

10.1097/INF.0000000000001701

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin (IL)-12 is composed of p35 and p40 subunits; in this case, IL-12p40 deficiency is a rare genetic etiology of Mendelian susceptibility to mycobacterial disease. Salmonellosis has been reported in almost half of these patients and mostly present in recurrent extraintestinal form. In this report, we described an 18-month-old boy with absence of IL-12p40 production suffering from chronic disseminated nontyphoidal salmonellosis. To the best of our knowledge, this is the first-reported case.

引用

页码：90 / 93

页数：4

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