Prognostic significance of L-type amino-acid transporter 1 expression in surgically resected pancreatic cancer

被引：156
作者：
Kaira, K. [1 ,2 ]
Sunose, Y. [3 ]
Arakawa, K. [4 ]
Ogawa, T. [4 ]
Sunaga, N. [1 ]
Shimizu, K. [3 ]
Tominaga, H. [5 ]
Oriuchi, N. [6 ]
Itoh, H. [7 ]
Nagamori, S. [8 ]
Kanai, Y. [8 ]
Segawa, A. [2 ]
Furuya, M. [2 ]
Mori, M. [1 ]
Oyama, T. [2 ]
Takeyoshi, I. [3 ]
机构：
[1] Gunma Univ, Grad Sch Med, Dept Med & Mol Sci, Maebashi, Gunma 3718511, Japan
[2] Gunma Univ, Grad Sch Med, Dept Diagnost Pathol, Maebashi, Gunma 3718511, Japan
[3] Gunma Univ, Grad Sch Med, Dept Thorac & Visceral Organ Surg, Maebashi, Gunma 3718511, Japan
[4] Maebashi Red Cross Hosp, Dept Surg, Maebashi, Gunma, Japan
[5] Gunma Univ, Grad Sch Med, Dept Mol Imaging, Maebashi, Gunma 3718511, Japan
[6] Gunma Univ, Grad Sch Med, Dept Diagnost Radiol & Nucl Med, Maebashi, Gunma 3718511, Japan
[7] Maebashi Red Cross Hosp, Dept Pathol, Maebashi, Gunma, Japan
[8] Osaka Univ, Grad Sch Med, Div Biosyst Pharmacol, Osaka, Japan
来源：
BRITISH JOURNAL OF CANCER | 2012年 / 107卷 / 04期
关键词：
LAT1; CD98; pancreatic cancer; amino-acid transporter; prognostic factor; Ki-67; THYMIC EPITHELIAL TUMORS; LYMPH-NODE METASTASES; CELL LUNG-CANCER; CD98; EXPRESSION; DUCTAL ADENOCARCINOMA; LAT1; CARCINOMA; SURVIVAL; ANGIOGENESIS; MALIGNANCY;
D O I：
10.1038/bjc.2012.310
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
BACKGROUND: The expression of L-type amino-acid transporter 1 (LAT1) is tumour-specific and has been shown to have essential roles in cell growth and survival. However, little is known regarding the clinical significance of LAT1 expression in pancreatic cancer. This study was conducted to determine the prognostic significance of LAT1 expression. METHODS: A total of 97 consecutive patients with surgically resected pathological stage I-IV pancreatic ductal adenocarcinoma were retrospectively reviewed. Tumour sections were stained by immunohistochemistry for LAT1, CD98, Ki-67 and vascular endothelial growth factor (VEGF), and microvessel density was determined by CD34 and p53. RESULTS: L-type amino-acid transporter 1 and CD98 were highly expressed in 52.6% (51/97) and 56.7% (55/97) of cases, respectively (P = 0.568). The expression of LAT1 within pancreatic cancer cells was significantly associated with disease stage, tumour size, Ki-67, VEGF, CD34, p53 and CD98. L-type amino-acid transporter 1 expression was confirmed to be a significant prognostic factor for predicting poor outcome by multivariate analysis. CONCLUSION: L-type amino-acid transporter 1 expression is a promising pathological marker for the prediction of outcome in patients with pancreatic cancer. British Journal of Cancer (2012) 107, 632-638. doi:10.1038/bjc.2012.310 www.bjcancer.com Published online 17 July 2012 (C) 2012 Cancer Research UK
引用
收藏
页码：632 / 638
页数：7
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