Nanoscale ZnO-based photosensitizers for photodynamic therapy

被引：65

作者：

Yi, Caixia ^{[1
]}

Yu, Zhihai ^{[2
]}

Ren, Qian ^{[3
]}

Liu, Xian ^{[1
]}

Wang, Yan ^{[1
]}

Sun, Xin ^{[1
]}

Yin, Shuanghong ^{[1
]}

Pan, Jun ^{[3
]}

Huang, Xiao ^{[1
,4
,5
]}

机构：

[1] Tongren Univ, Inst Nanomed & Biomat, Sch Sports & Hlth Sci, Tongren 554300, Peoples R China

[2] Three Gorges Cent Hosp, Dept Urol Surg, Chongqing 404000, Peoples R China

[3] Chongqing Univ, Minist Educ, Coll Bioengn, Key Lab Biorheol Sci & Technol, Chongqing 400044, Peoples R China

[4] Inst Cultural & Technol Ind Innovat Tongren, Tongren 554300, Peoples R China

[5] Zunyi Med Univ, Guizhou Prov Coll, Based Key Lab Tumor Prevent & Treatment Distinct, Zunyi 563000, Guizhou, Peoples R China

来源：

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY | 2020年 / 30卷

基金：

中国国家自然科学基金;

关键词：

ZnO-based photosensitizer; Photodynamic therapy; Photoexcitation; Reactive oxygen species; Synergistic effect; SQUAMOUS-CELL CARCINOMA; ENHANCED PHOTOCATALYSIS; ANTIBACTERIAL ACTIVITY; BACTERIAL-INHIBITION; CANCER; OXIDE; NANOPARTICLES; GENERATION; EFFICIENT; UV;

D O I：

10.1016/j.pdpdt.2020.101694

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Due to the ability to induce the generation of reactive oxygen species (ROS) under light irradiation, ZnO nanoparticles show great potential in photodynamic therapy (PDT). Photo-triggered ROS production by ZnO nanoparticles and the resulting phototoxicity are efficient in killing cancer cells. This review highlights the recent exciting progress on the nanoscale ZnO-based photosensitizers (PSs) for PDT. Both the semplice ZnO nanoparticles as the PSs and the various chemicals (organic PS, dopant, metal and chemotherapeutic drugs) modified ZnO nanoparticles as the PSs show good ROS generation efficiency. The productive rate of ROS, the wavelength of exciting lights, and the therapeutic effect can be altered by doping different chemicals into ZnO nanoparticles at will. Additionally, we give some outlook on the design and functionalization of next-generation ZnO nanoparticles for more effective anti-cancer applications.

引用

页数：7

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