Liver X receptor and peroxisome proliferator-activated receptor agonist from Cornus alternifolia

被引:16
作者
He, Yang-Qing [1 ,2 ]
Ma, Guo-Yi [1 ]
Peng, Jiang-nan [3 ]
Ma, Zhan-Ying [2 ]
Hamann, Mark T. [1 ]
机构
[1] Univ Mississippi, Sch Pharm, Dept Pharmacognosy, University, MS 38677 USA
[2] Xian Univ Technol, Dept Appl Chem, Xian 710048, Peoples R China
[3] Univ Texas Hlth Sci Ctr San Antonio, Dept Pharmacol, San Antonio, TX 78229 USA
来源
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS | 2012年 / 1820卷 / 07期
关键词
Peroxisome proliferator-activated receptors; Liver X receptors; Cornus alternifolia; Iridoid glycosides; IRIDOID GLUCOSIDES; ANTHOCYANINS; REQUIREMENTS; CONSTITUENTS; ANTIOXIDANT; MECHANISMS; PRINCIPLES; GLYCOSIDES; TARGETS; LEAVES;
D O I
10.1016/j.bbagen.2012.02.004
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Background: Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear receptors superfamily and are transcription factors activated by specific ligands. Liver X receptors (LXR) belong to the nuclear hormone receptors and have been shown to play an important role in cholesterol homeostasis. From the previous screening of several medicinal plants for potential partial PPAR gamma agonists, the extracts of Cornus alternifolia were found to exhibit promising bioactivity. In this paper, we report the isolation and structural elucidation of four new compounds and their potential as ligands for PPAR. Methods: The new compounds were extracted from the leaves of C alternifolia and fractionated by high-performance liquid chromatography. Their structures were elucidated on the basis of spectroscopic evidence and analysis of their hydrolysis products. Results: Three new iridoid glycosides including an iridolactone, alternosides A-C (1-3), a new megastigmane glycoside, cornalternoside (4) and 10 known compounds, were obtained from the leaves of C alternifolia. Kaempferol-3-O-beta-glucopyranoside (5) exhibited potent agonistic activities for PPAR alpha, PPAR gamma and LXR with EC50 values of 0.62, 3.0 and 1.8 mu M, respectively. Conclusions: We isolated four new and ten known compounds from C. alternifolia, and one known compound showed agonistic activities for PPAR alpha, PPAR gamma and LXR. General significance: Compound 1 is the first example of a naturally occurring iridoid glycoside containing a beta-glucopyranoside moiety at C-6. Published by Elsevier B.V.
引用
收藏
页码:1021 / 1026
页数:6
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