Kinesins and cancer

被引：400

作者：

Rath, Oliver ^{[1
]}

Kozielski, Frank ^{[1
]}

机构：

[1] Beatson Inst Canc Res, Glasgow G61 1BD, Lanark, Scotland

来源：

NATURE REVIEWS CANCER | 2012年 / 12卷 / 08期

关键词：

CENTROMERE-ASSOCIATED KINESIN; SPINDLE PROTEIN INHIBITOR; CELL LUNG-CANCER; SMALL-MOLECULE INHIBITOR; HUMAN HEPATOCELLULAR-CARCINOMA; ATP-COMPETITIVE INHIBITORS; MICROTUBULE-BINDING SITE; METASTATIC BREAST-CANCER; MESSENGER-RNA EXPRESSION; ALBUMIN-BOUND PACLITAXEL;

D O I：

10.1038/nrc3310

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Kinesins are a family of molecular motors that travel unidirectionally along microtubule tracks to fulfil their many roles in intracellular transport or cell division. Over the past few years kinesins that are involved in mitosis have emerged as potential targets for cancer drug development. Several compounds that inhibit two mitotic kinesins (EG5 (also known as KIF11) and centromere-associated protein E (CENPE)) have entered Phase I and II clinical trials either as monotherapies or in combination with other drugs. Additional mitotic kinesins are currently being validated as drug targets, raising the possibility that the range of kinesin-based drug targets may expand in the future.

引用

页码：527 / 539

页数：13

共 216 条

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