Biologic features of Hodgkin lymphoma and the development of biologic prognostic factors in Hodgkin lymphoma: Tumor and microenvironment

被引：33

作者：

Hsi, Eric D. ^{[1
]}

机构：

[1] Cleveland Clin, Dept Clin Pathol, Cleveland, OH 44106 USA

来源：

LEUKEMIA & LYMPHOMA | 2008年 / 49卷 / 09期

关键词：

lymphoma and Hodgkin disease; prognostic markers; biomarkers; microenviroment; prognosis;

D O I：

10.1080/10428190802163339

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Classical Hodgkin lymphoma is now recognised as a B-cell lymphoma. Improved therapy has increased cure rates dramatically; however, relapse and death still occurs in a minority of patients. Much has been learned about the biology of Hodgkin and Reed Sternberg cells and their interactions with the microenvironment, which has informed studies exploring biologic markers that may improve upon clinical prognostic models. This manuscript reviews recent advances in our understanding of the pathobiology of cHL with an emphasis on biologic prognostic markers.

引用

页码：1668 / 1680

页数：13

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