The enantioselective total synthesis of the antitumor macrolide natural product rhizoxin D

被引：27
|
作者：
Lafontaine, JA [1 ]
Provencal, DP [1 ]
Gardelli, C [1 ]
Leahy, JW [1 ]
机构：
[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA
来源：
TETRAHEDRON LETTERS | 1999年 / 40卷 / 22期
基金：
美国国家科学基金会;
关键词：
D O I：
10.1016/S0040-4039(99)00731-5
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A convergent, enantioselective total synthesis of rhizoxin D (didesepoxy-rhizoxin), a potent antitumor natural product, was achieved via three critical olefinations, including a Horner-Emmons macrocyclization. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：4145 / 4148
页数：4
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