TET family proteins: new players in gliomas

被引：22
作者：
Bian, Er-Bao [1 ,2 ]
Zong, Gang [1 ,2 ]
Xie, Yong-Sheng [1 ,2 ]
Meng, Xiao-Ming [3 ]
Huang, Cheng [3 ]
Li, Jun [3 ]
Zhao, Bing [1 ,2 ]
机构：
[1] Anhui Med Univ, Affiliated Hosp 2, Dept Neurosurg, Hefei 230601, Peoples R China
[2] Anhui Med Univ, Cerebral Vasc Dis Res Ctr, Hefei 230601, Anhui, Peoples R China
[3] Anhui Med Univ, Sch Pharm, Hefei 230032, Peoples R China
来源：
JOURNAL OF NEURO-ONCOLOGY | 2014年 / 116卷 / 03期
基金：
美国国家科学基金会;
关键词：
Gliomas; TETs; 5hmc; Demethylation; ACTIVE DNA DEMETHYLATION; ACETYLGLUCOSAMINE TRANSFERASE OGT; GENE-EXPRESSION; STRUCTURAL BASIS; 5-HYDROXYMETHYLCYTOSINE; METHYLATION; 5-METHYLCYTOSINE; MUTATIONS; BINDING; HYDROXYLATION;
D O I：
10.1007/s11060-013-1328-7
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
DNA methylation at the 5-position of cytosine (5mC) in the mammalian genome has emerged as a pivotal epigenetic event that plays important roles in development, aging and disease. The three members of the TET protein family, which convert 5mC to 5-hydroxymethylcytosine, has provided a potential mechanism resulting in DNA demethylation and maintaining cellular identity. Recent studies have shown that epigenetic modifications play a key role in the regulation of the molecular pathogenesis of gliomas. In this review we focus on demonstrating the TET proteins in DNA demethylation and transcriptional regulation of different target genes. In addition, we address the role of TET proteins in gliomas. This review will provide valuable insights into the potential targets of gliomas, and may open the possibility of novel therapeutic approaches to this fatal disease.
引用
收藏
页码：429 / 435
页数：7
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