CeCl3•7H2O CATALYZED, MICROWAVE-ASSISTED HIGH-YIELD SYNTHESIS OF α-AMINOPHOSPHONATES AND THEIR BIOLOGICAL STUDIES

被引：12
作者：
Varalakshmi, M. [1 ]
Srinivasulu, D. [1 ]
Rajasekhar, D. [1 ]
Raju, C. Naga [1 ]
Sreevani, S. [2 ]
机构：
[1] Sri Venkateswara Univ, Dept Chem, Tirupati 517502, Andhra Pradesh, India
[2] Sri Venkateswara Univ, Dept Microbiol, Tirupati 517502, Andhra Pradesh, India
来源：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2014年 / 189卷 / 01期
关键词：
-Aminophosphonates; Lewis acid catalyst (CeCl3 center dot 7H(2)O); microwave irradiation; antimicrobial and antioxidant activities; SCAVENGING PROPERTIES; AMINO PHOSPHONATES; CHLORIDE; BROMOPHENOLS; SYSTEM; ACID;
D O I：
10.1080/10426507.2013.798785
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A new class of diethyl(3,5-dibromo-4-hydroxyphenylamino) (substituted phenyl/heterocyclic) methylphosphonates 4(a-j) has been synthesized by one-pot three component simultaneous reaction (Kabachnik-Fields) of 4-amino-2,6-dibromophenol 1, substituted heterocyclic/phenyl aldehydes 2(a-j), and diethylphosphite 3 using a Lewis acid catalyst, CeCl(3)7H(2)O (5mol%) under microwave irradiation as well as conventional conditions. It was observed that microwave irradiation method is more facile, efficient, and advantageous with respect to reaction time and yields. The structures of all the synthesized compounds were supported by analyzing IR, H-1/C-13/P-31 NMR, and mass spectral data. The synthesized compounds were screened for their in vitro antimicrobial and antioxidant activities.
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页码：106 / 112
页数：7
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