Erythro-myeloid progenitors: "Definitive" hematopoiesis in the conceptus prior to the emergence of hematopoietic stem cells

被引：113

作者：

Frame, Jenna M. ^{[1
,2
]}

McGrath, Kathleen E. ^{[1
]}

Palis, James ^{[1
]}

机构：

[1] Univ Rochester, Med Ctr, Ctr Pediat Biomed Res, Dept Pediat, Rochester, NY 14642 USA

[2] Univ Rochester, Med Ctr, Dept Pathol & Lab Med, Rochester, NY 14642 USA

来源：

BLOOD CELLS MOLECULES AND DISEASES | 2013年 / 51卷 / 04期

关键词：

Yolk sac; Hematopoiesis; Erythro-myeloid progenitors; Embryogenesis; MOUSE YOLK-SAC; PRIMITIVE ERYTHROBLASTS; HEMOGENIC ENDOTHELIUM; FETAL LIVER; EMBRYONIC-DEVELOPMENT; COMMON PRECURSOR; BLOOD FORMATION; RETINOIC ACID; RUNX1; MACROPHAGES;

D O I：

10.1016/j.bcmd.2013.09.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Erythro-myeloid progenitors (EMP) serve as a major source of hematopoiesis in the developing conceptus prior to the formation of a permanent blood system. In this review, we summarize the current knowledge regarding the emergence, fate, and potential of this hematopoietic stem cell (HSC)-independent wave of hematopoietic progenitors, focusing on the murine embryo as a model system. A better understanding of the temporal and spatial control of hematopoietic emergence in the embryo will ultimately improve our ability to derive hematopoietic stem and progenitor cells from embryonic stem cells and induced pluripotent stem cells to serve therapeutic purposes. (C) 2013 Elsevier Inn All rights reserved.

引用

页码：220 / 225

页数：6

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