G-protein-coupled receptors: Molecular mechanisms involved in receptor activation and selectivity of G-protein recognition

被引:487
作者
Wess, J
机构
[1] Laboratory of Bioorganic Chemistry, Natl. Inst. Diabet. Digest. K., NIH, Bethesda
[2] Natl. Inst. Diabet. Digest. K., Laboratory of Bioorganic Chemistry, Bethesda, MD 20892
关键词
signal transduction; receptor structure; receptor/G-protein interactions;
D O I
10.1096/fasebj.11.5.9141501
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
G-protein-coupled receptors (GPCRs) play fundamental roles in regulating the activity of virtually every body cell, Upon binding of extracellular ligands, GPCRs interact with a specific subset of heterotrimeric G-proteins that can then, in their activated forms, inhibit or activate various effector enzymes and/or ion channels. Molecular cloning studies have shown that GPCRs form one of the largest protein families found in nature, and it is estimated that approximately 1000 different such receptors exist in mammals. The molecular mechanisms involved in GPCR function, particularly the molecular modes of receptor activation and G-protein recognition and activation, have therefore become the research focus of an ever increasing number of laboratories. This review Trill summarize and attempt to integrate recent data derived from structural, molecular genetic, biochemical, and biophysical studies that have shed new light on these processes.
引用
收藏
页码:346 / 354
页数:9
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