Mechanisms of Drug-induced Liver Injury

被引：241

作者：

Yuan, Liyun ^{[1
]}

Kaplowitz, Neil ^{[1
]}

机构：

[1] Univ So Calif, Keck Sch Med, Dept Med, USC Res Ctr Liver Dis, Los Angeles, CA 90033 USA

来源：

CLINICS IN LIVER DISEASE | 2013年 / 17卷 / 04期

关键词：

Idiosyncratic drug-induced liver injury; Cell death; Reactive metabolites; Oxidative stress; Stress signaling; Mitochondria; Adaptive immunity; HLA associations; MITOCHONDRIAL DYSFUNCTION; POSITIONAL ISOMER; ORAL MEDICATIONS; CELL-DEATH; ACETAMINOPHEN; NECROSIS; PROTEIN; 3'-HYDROXYACETANILIDE; INHIBITION; APOPTOSIS;

D O I：

10.1016/j.cld.2013.07.002

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Drug-induced liver injury (DILI) represents a broad spectrum of liver manifestations. However, the most common manifestation is hepatocyte death following drug intake. DILI can be predictable and dose dependent with a notable example of acetaminophen toxicity. Idiosyncratic DILI occurs in an unpredictable fashion at low frequencies, implying that environmental and genetic factors alter the susceptibility of individuals to the insult (drugs).

引用

页码：507 / +

页数：13

共 64 条

[1] Drug-induced liver injury [J].

Abboud, Gebran ;

Kaplowitz, Neil .

DRUG SAFETY, 2007, 30 (04) :277-294

[2] Regulation of JNK signaling by GSTp [J].

Adler, V ;

Yin, ZM ;

Fuchs, SY ;

Benezra, M ;

Rosario, L ;

Tew, KD ;

Pincus, MR ;

Sardana, M ;

Henderson, CJ ;

Wolf, CR ;

Davis, RJ ;

Ronai, Z .

EMBO JOURNAL, 1999, 18 (05) :1321-1334

[3] High-Mobility Group Box-1 Protein and Keratin-18, Circulating Serum Proteins Informative of Acetaminophen-Induced Necrosis and Apoptosis In Vivo [J].

Antoine, Daniel J. ;

Williams, Dominic P. ;

Kipar, Anja ;

Jenkins, Rosalind E. ;

Regan, Sophie L. ;

Sathish, Jean G. ;

Kitteringham, Neil R. ;

Park, B. Kevin .

TOXICOLOGICAL SCIENCES, 2009, 112 (02) :521-531

[4] NECROSTATIN-1 ATTENUATES MITOCHONDRIAL DYSFUNCTION IN NEURONS AND ASTROCYTES FOLLOWING NEONATAL HYPOXIA-ISCHEMIA [J].

Chavez-Valdez, R. ;

Martin, L. J. ;

Flock, D. L. ;

Northington, F. J. .

NEUROSCIENCE, 2012, 219 :192-203

[5] Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation [J].

Cho, YoungSik ;

Challa, Sreerupa ;

Moquin, David ;

Genga, Ryan ;

Ray, Tathagat Dutta ;

Guildford, Melissa ;

Chan, Francis Ka-Ming .

CELL, 2009, 137 (06) :1112-1123

[6] The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system [J].

Copple, Ian M. ;

Goldring, Christopher E. ;

Jenkins, Rosslind E. ;

Chia, Alvin J. L. ;

Randle, Laura E. ;

Hayes, John D. ;

Kitteringham, Neil R. ;

Park, B. Kevin .

HEPATOLOGY, 2008, 48 (04) :1292-1301

[7] The Nrf2-Keapl defence pathway: Role in protection against drug-induced toxicity [J].

Copple, Ian M. ;

Goldring, Christopher E. ;

Kitteringham, Neil R. ;

Park, B. Kevin .

TOXICOLOGY, 2008, 246 (01) :24-33

[8] Drug-Induced Autoimmune-Like Hepatitis [J].

Czaja, Albert J. .

DIGESTIVE DISEASES AND SCIENCES, 2011, 56 (04) :958-976

[9] HLA-B☆5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin [J].

Daly, Ann K. ;

Donaldson, Peter T. ;

Bhatnagar, Pallav ;

Shen, Yufeng ;

Pe'er, Itsik ;

Floratos, Aris ;

Daly, Mark J. ;

Goldstein, David B. ;

John, Sally ;

Nelson, Matthew R. ;

Graham, Julia ;

Park, B. Kevin ;

Dillon, John F. ;

Bernal, William ;

Cordell, Heather J. ;

Pirmohamed, Munir ;

Aithal, Guruprasad P. ;

Day, Christopher P. .

NATURE GENETICS, 2009, 41 (07) :816-U71

[10] In Vitro Inhibition of the Bile Salt Export Pump Correlates with Risk of Cholestatic Drug-Induced Liver Injury in Humans [J].

Dawson, Sarah ;

Stahl, Simone ;

Paul, Nikki ;

Barber, Jane ;

Kenna, J. Gerald .

DRUG METABOLISM AND DISPOSITION, 2012, 40 (01) :130-138

← 1 2 3 4 5 6 7 →