Polyacrylic acid@zeolitic imidazolate framework-8 nanoparticles with ultrahigh drug loading capability for pH-sensitive drug release

被引：241

作者：

Ren, Hong ^{[1
]}

Zhang, Lingyu ^{[1
]}

An, Jiping ^{[2
]}

Wang, Tingting ^{[3
]}

Li, Lu ^{[1
]}

Si, Xiaoyan ^{[1
]}

He, Liu ^{[1
]}

Wu, Xiaotong ^{[1
]}

Wang, Chungang ^{[1
]}

Su, Zhongmin ^{[1
]}

机构：

[1] NE Normal Univ, Fac Chem, Changchun 130024, Peoples R China

[2] Jilin Univ, Hosp Stomatol, Changchun 130021, Peoples R China

[3] Changchun Univ Sci & Technol, Sch Chem & Environm Engn, Changchun 130022, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 08期

基金：

中国国家自然科学基金;

关键词：

CORE-SHELL; DELIVERY; MICROSPHERES; FABRICATION; NANOSPHERES; ZIF-8;

D O I：

10.1039/c3cc47666a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The polyacrylic acid@zeolitic imidazolate framework-8 (PAA@ZIF-8) nanoparticles (NPs) were first fabricated using a facile and simple route. It is worthwhile noting that the as-fabricated PAA@ZIF-8 NPs possessed ultrahigh doxorubicin (DOX) loading capability (1.9 g DOX g(-1) NPs), which were employed as pH-dependent drug delivery vehicles.

引用

页码：1000 / 1002

页数：3

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