Donepezil decreases annual rate of hippocampal atrophy in suspected prodromal Alzheimer's disease

被引：104

作者：

Dubois, Bruno ^{[1
,2
,3
]}

Chupin, Marie ^{[2
]}

Hampel, Harald ^{[1
,2
,3
]}

Lista, Simone ^{[1
,2
]}

Cavedo, Enrica ^{[1
,2
]}

Croisile, Bernard ^{[4
]}

Tisserand, Guy Louis ^{[4
]}

Touchon, Jacques ^{[5
]}

Bonafe, Alain ^{[5
]}

Ousset, Pierre Jean ^{[6
]}

Ameur, Amir Ait ^{[7
]}

Rouaud, Olivier ^{[8
]}

Ricolfi, Frederic ^{[8
]}

Vighetto, Alain ^{[4
]}

Pasquier, Florence ^{[9
]}

Delmaire, Christine ^{[10
]}

Ceccaldi, Mathieu ^{[11
]}

Girard, Nadine ^{[11
]}

Dufouil, Carole ^{[12
]}

Lehericy, Stephane ^{[2
,13
]}

Tonelli, Isabelle ^{[14
]}

Duveau, Francoise ^{[14
]}

Colliot, Olivier ^{[2
]}

Garnero, Line ^{[2
]}

Sarazin, Marie ^{[1
,2
,3
]}

Dormont, Didier ^{[2
,3
,15
]}

机构：

[1] Hop La Pitie Salpetriere, AP HP, Dept Neurol, Inst Memoire & Malad Alzheimer IM2A, Paris, France

[2] CNRS, UMR S975, INSERM, Inst Cerveau & Moelle Epiniere ICM, Paris, France

[3] Univ Paris 06, Sorbonne Univ, Paris, France

[4] Hop Neurol & Neurochirurg P Wertheimer, Lyon, France

[5] CHR Montpellier, F-34059 Montpellier, France

[6] Hop Casselardit, Toulouse, France

[7] Clin Pasteur, Toulouse, France

[8] Hop Gen, Dijon, France

[9] Univ Lille Nord France UDSL, CHRU, Neurol Clin, Lille, France

[10] Hop Roger Salengro, Lille, France

[11] Hop Enfants La Timone, Marseille, France

[12] Univ Bordeaux, Ctr INSERM Epidemiol & Biostat U897, Bordeaux, France

[13] Hop La Pitie Salpetriere, ICM, CENIR, Neuroimaging Unit, Paris, France

[14] Eisai SAS, Paris 2, France

[15] Hop La Pitie Salpetriere, Dept Neuroradiol, Paris, France

来源：

ALZHEIMERS & DEMENTIA | 2015年 / 11卷 / 09期

关键词：

Randomized controlled trial; Amnestic MCI; MRI; Volumetric imaging; Donepezil; Rate of atrophy; Hippocampus; Whole brain analysis; Alzheimer's disease; Prodromal Alzheimer's disease; Mild cognitive impairment; Biomarker; Therapy; AMNESTIC SYNDROME; BRAIN LOSS; PROGRESSION; MRI; SEGMENTATION; TRAJECTORIES; VALIDATION; BIOMARKER; TRIAL;

D O I：

10.1016/j.jalz.2014.10.003

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: The purpose of this study was to study the effect of donepezil on the rate of hippocampal atrophy in prodromal Alzheimer's disease (AD). Methods: A double-blind, randomized, placebo-controlled parallel group design using donepezil (10 mg/day) in subjects with suspected prodromal AD. Subjects underwent two brain magnetic resonance imaging scans (baseline and final visit). The primary efficacy outcome was the annualized percentage change (APC) of total hippocampal volume (left 1 right) measured by an automated segmentation method. Results: Two-hundred and sixteen only subjects were randomized across 28 French expert clinical sites. In the per protocol population (placebo 5 92 and donepezil 5 82), the donepezil group exhibited a significant reduced rate of hippocampal atrophy (APC=-1.89%) compared with the placebo group (APC=-3.47%), P<. 001. There was no significant difference in neuropsychological performance between treatment groups. Discussion: A 45% reduction of rate of hippocampal atrophy was observed in prodromal AD following 1 year of treatment with donepezil compared with placebo. (C) 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

引用

页码：1041 / 1049

页数：9

共 50 条

[1] Reduced Regional Cortical Thickness Rate of Change in Donepezil-Treated Subjects With Suspected Prodromal Alzheimer's Disease
Cavedo, Enrica
Dubois, Bruno
Colliot, Olivier
Lista, Simone
Croisile, Bernard
Tisserand, Guy Louis
Touchon, Jacques
Bonafe, Alain
Ousset, Pierre J.
Rouaud, Olivier
Ricolfi, Frederic
Vighetto, Alain
Pasquier, Florence
Galluzzi, Samantha
Delmaire, Christine
Ceccaldi, Mathieu
Girard, Nadine
Lehericy, Stephane
Duveau, Francoise
Chupin, Marie
Sarazin, Marie
Dormont, Didier
Hampel, Harald
JOURNAL OF CLINICAL PSYCHIATRY, 2016, 77 (12) : E1631 - E1638
[2] Progression of hippocampal subfield atrophy and asymmetry in Alzheimer's disease
Xu, Jingjing
Tan, Sijia
Wen, Jiaqi
Zhang, Minming
Xu, Xiaojun
EUROPEAN JOURNAL OF NEUROSCIENCE, 2024, 60 (08) : 6091 - 6106
[3] Donepezil decreases heart rate in elderly patients with Alzheimer's disease
Pu, Zhengping
Xu, Wenjie
Lin, Yong
Shen, Juanhui
Sun, Yunying
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, 2019, 57 (02) : 94 - 100
[4] Corpus Callosum Atrophy Rate in Mild Cognitive Impairment and Prodromal Alzheimer's Disease
Elahi, Sahar
Bachman, Alvin H.
Lee, Sang Han
Sidtis, John J.
Ardekani, Babak A.
JOURNAL OF ALZHEIMERS DISEASE, 2015, 45 (03) : 921 - 931
[5] Multivariate Prediction of Hippocampal Atrophy in Alzheimer's Disease
Liedes, Hilkka
Lotjonen, Jyrki
Kortelainen, Juha M.
Novak, Gerald
van Gils, Mark
Gordon, Mark Forrest
JOURNAL OF ALZHEIMERS DISEASE, 2019, 68 (04) : 1453 - 1468
[6] Predictors of cognitive decline and treatment response in a clinical trial on suspected prodromal Alzheimer's disease
Teipel, Stefan J.
Cavedo, Enrica
Grothe, Michel J.
Lista, Simone
Galluzzi, Samantha
Colliot, Olivier
Chupin, Marie
Bakardjian, Hovagim
Dormont, Didier
Dubois, Bruno
Hampel, Harald
NEUROPHARMACOLOGY, 2016, 108 : 128 - 135
[7] Fractional anisotropy of the fornix and hippocampal atrophy in Alzheimer's disease
Kantarci, Kejal
FRONTIERS IN AGING NEUROSCIENCE, 2014, 6
[8] MRI-based Alzheimer's disease-resemblance atrophy index in the detection of preclinical and prodromal Alzheimer's disease
Liu, Wanting
Au, Lisa Wing Chi
Abrigo, Jill
Luo, Yishan
Wong, Adrian
Lam, Bonnie Yin Ka
Fan, Xiang
Kwan, Pauline Wing Lam
Ma, Hon Wing
Ng, Anthea Yee Tung
Chen, Sirong
Leung, Eric Yim Lung
Ho, Chi Lai
Wong, Simon Ho Man
Chu, Winnie C. W.
Ko, Ho
Lau, Alexander Yuk Lun
Shi, Lin
Mok, Vincent Chung Tong
AGING-US, 2021, 13 (10): : 13496 - 13514
[9] Grey matter atrophy in prodromal stage of dementia with Lewy bodies and Alzheimer's disease
Blanc, Frederic
Colloby, Sean J.
Cretin, Benjamin
de Sousa, Paulo Loureiro
Demuynck, Catherine
O'Brien, John T.
Martin-Hunyadi, Catherine
McKeith, Ian
Philippi, Nathalie
Taylor, John-Paul
ALZHEIMERS RESEARCH & THERAPY, 2016, 8
[10] Grey matter atrophy in prodromal stage of dementia with Lewy bodies and Alzheimer’s disease
Frederic Blanc
Sean J. Colloby
Benjamin Cretin
Paulo Loureiro de Sousa
Catherine Demuynck
John T. O’Brien
Catherine Martin-Hunyadi
Ian McKeith
Nathalie Philippi
John-Paul Taylor
Alzheimer's Research & Therapy, 8

← 1 2 3 4 5 →