Immunomodulatory activities of Lactobacillus rhamnosus ZDY114 and donkey milk in BALB/c mice

被引:17
|
作者
Peng, Shanshan [1 ,4 ]
Yang, Youjun [1 ]
Li, Shengjie [1 ]
Wu, Qinglong [3 ]
Shah, Nagendra P. [3 ]
Wei, Hua [1 ,2 ]
Xu, Feng [2 ]
机构
[1] Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Peoples R China
[2] Nanchang Univ, Jiangxi OAI Joint Res Inst, Nanchang 330047, Peoples R China
[3] Univ Hong Kong, Sch Biol Sci, Hong Kong, Hong Kong, Peoples R China
[4] Jiangxi Acad Med Sci, Nanchang 330006, Peoples R China
关键词
FRACTION; PROBIOTICS; GG;
D O I
10.1016/j.idairyj.2013.07.018
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
The immunomodulatory activity of Lactobacillus rhamnosus ZDY114 and donkey milk in BALB/c mice was evaluated by assessing the splenic lymphocyte transformation, haemolytic complement activity, carbon clearance ability and natural killer cell activity. Results showed donkey milk (5 g kg(-1)) in combination with L. rhamnosus ZDY114 (5 x 10(7) cfu mL(-1)) exhibited a significant increase in splenic lymphocyte proliferation, carbon granule engulfing ability and natural killer cell activity when compared with donkey milk or L. rhamnosus ZDY114 alone (p < 0.05). An elevated response in serum haemolytic activity was only observed when compared with L. rhamnosus ZDY114. In conclusion, donkey milk (5 g kg(-1)) in combination with L. rhamnosus ZDY114 (5 x 10(7) cfu mL(-1)) was able to enhance specific immune functions. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码:263 / 266
页数:4
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