The endocannabinoid anandamide affects the synthesis of human syncytiotrophoblast-related proteins

被引：11

作者：

Costa, M. A. ^{[1
]}

Fonseca, B. M. ^{[2
]}

Mendes, A. ^{[3
]}

Braga, J. ^{[3
]}

Teixeira, N. A. ^{[2
]}

da Silva, Georgina Correia ^{[2
]}

机构：

[1] Univ Porto, Fac Farm, Lab Bioquim, Dept Ciencias Biol, P-4050313 Oporto, Portugal

[2] Univ Porto, Fac Farm, Lab Bioquim, UCIBIO,REQUIMTE,Dept Ciencias Biol, P-4050313 Oporto, Portugal

[3] Ctr Hosp Porto, Ctr Materno Infantil Norte, Serv Obstet, Dept Mulher & Crianca, Oporto, Portugal

来源：

CELL AND TISSUE RESEARCH | 2015年 / 362卷 / 02期

关键词：

Anandamide; Endocannabinoid signalling; Placental proteins; Human syncytiotrophoblast; Placenta; HUMAN PLACENTAL SYNCYTIOTROPHOBLASTS; IN-VITRO; KINASE-A; CELLS; DIFFERENTIATION; EXPRESSION; PATHWAYS; LEPTIN; SYNCYTIALIZATION; CYTOTROPHOBLASTS;

D O I：

10.1007/s00441-015-2236-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The human syncytiotrophoblast (hST) has a major role in the production of important placental hormones. Several molecules regulate hST endocrine function but the role of endocannabinoids in this process is still unknown. Here, we report that the endocannabinoid anandamide (AEA) decreased cAMP levels, impaired human chorionic gonadotropin secretion, placental alkaline phosphatase activity and decreased aromatase mRNA levels and protein expression, through cannabinoid (CB) receptor activation. AEA also downregulated leptin and placental protein 13 transcription, though via a CB receptor-independent mechanism. All this evidence suggests AEA is a novel modulator of hormone synthesis by the syncytiotrophoblast, supporting the importance of the endocannabinoid signalling in placental function.

引用

页码：441 / 446

页数：6

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