The Whereabouts of microRNA Actions: Cytoplasm and Beyond

被引：135

作者：

Leung, Anthony K. L. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Biochem & Mol Biol, Baltimore, MD 21205 USA

来源：

TRENDS IN CELL BIOLOGY | 2015年 / 25卷 / 10期

基金：

美国国家卫生研究院;

关键词：

EUKARYOTIC MESSENGER-RNAS; TRANSLATIONAL REPRESSION; DEPENDENT LOCALIZATION; ENDOPLASMIC-RETICULUM; ARGONAUTE PROTEINS; IN-VIVO; MIRNA; COMPLEXES; PHOSPHORYLATION; POLYSOMES;

D O I：

10.1016/j.tcb.2015.07.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

MicroRNAs (miRNAs) are a conserved class of approximately 22 nucleotide (nt) short noncoding RNAs that normally silence gene expression via translational repression and/or degradation of targeted mRNAs in plants and animals. Identifying the whereabouts of miRNAs potentially informs miRNA functions, some of which are perhaps specialized to specific cellular compartments. In this review, the significance of miRNA localizations in the cytoplasm, including those at RNA granules and endomembranes, and the export of miRNAs to extracellular space will be discussed. How miRNA localizations and functions are regulated by protein modifications on the core miRNA-binding protein Argonaute (AGO) during normal and stress conditions will be explored, and in conclusion new AGO partners, non-AGO miRNA-binding proteins, and the emergent understanding of miRNAs found in the nucleoplasm, nucleoli, and mitochondria will be discussed.

引用

页码：601 / 610

页数：10

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