Glutamine synthetase mutations that cause glutamine deficiency: mechanistic insights from molecular dynamics simulations

被引：2
|
作者：
Frieg, Benedikt [1 ]
Homeyer, Nadine [1 ]
Haeussinger, Dieter [2 ]
Gohlke, Holger [1 ]
机构：
[1] Heinrich Heine Univ, Inst Pharmaceut & Med Chem, D-40225 Dusseldorf, Germany
[2] Heinrich Heine Univ, Clin Gastroenterol Hepatol & Infect Dis, D-40225 Dusseldorf, Germany
来源：
EUROPEAN JOURNAL OF MEDICAL RESEARCH | 2014年 / 19卷
关键词：
Molecular Dynamic Simulation; Hepatic Encephalopathy; Glutamine Synthetase; Glutamine Synthetase Activity; Mutant R324C;
D O I：
10.1186/2047-783X-19-S1-S15
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
S15
引用
收藏
页数：3
相关论文
共 50 条
  • [41] Characterization of Vitis vinifera L glutamine synthetase and molecular cloning of cDNAs for the cytosolic enzyme
    Loulakakis, KA
    RoubelakisAngelakis, KA
    PLANT MOLECULAR BIOLOGY, 1996, 31 (05) : 983 - 992
  • [42] MOLECULAR-BASIS FOR DIFFERENTIAL EXPRESSION OF GLUTAMINE-SYNTHETASE IN RETINA GLIA AND NEURONS
    GROSSMAN, R
    FOX, LE
    GOROVITS, R
    BENDROR, I
    REISFELD, S
    VARDIMON, L
    MOLECULAR BRAIN RESEARCH, 1994, 21 (3-4): : 312 - 320
  • [43] Molecular evolution of duplicate copies of genes encoding cytosolic glutamine synthetase in Pisum sativum
    Walker, EL
    Weeden, NF
    Taylor, CB
    Green, P
    Coruzzi, GM
    PLANT MOLECULAR BIOLOGY, 1995, 29 (06) : 1111 - 1125
  • [44] GENETIC, MOLECULAR AND DEVELOPMENTAL ANALYSIS OF THE GLUTAMINE-SYNTHETASE ISOZYMES OF DROSOPHILA-MELANOGASTER
    CAGGESE, C
    BARSANTI, P
    VIGGIANO, L
    BOZZETTI, MP
    CAIZZI, R
    GENETICA, 1994, 94 (2-3) : 275 - 281
  • [45] Boron deficiency increases expressions of asparagine synthetase, glutamate dehydrogenase and glutamine synthetase genes in tobacco roots irrespective of the nitrogen source
    Beato, Victor M.
    Rexach, Jesus
    Teresa Navarro-Gochicoa, M.
    Camacho-Cristobal, Juan J.
    Begona Herrera-Rodriguez, M.
    Gonzalez-Fontes, Agustin
    SOIL SCIENCE AND PLANT NUTRITION, 2014, 60 (03) : 314 - 324
  • [46] Molecular cloning of Glutamine Synthetase cDNA from Lactuca sativa: Sequence analysis and gene expression during storage
    Department of Bioresource Production Science, Faculty of Agriculture, Kagawa University, Miki-Cho, Ikenobe 2393, Kagawa 761-0795, Japan
    不详
    Biotechnology, 2009, 2 (220-227) : 220 - 227
  • [47] Modeling the Regulation of the Activity of Glutamine Synthetase from Escherichia coli by Magnesium Ions
    Kazmiruk N.V.
    Boronovskiy S.E.
    Nartsissov Y.R.
    Biophysics, 2018, 63 (3) : 318 - 324
  • [48] Cloning and characterization of the glutamine synthetase gene from Chinese shrimp Fenneropenaeus chinensis
    Lai, Xiao Fang
    Gao, Huan
    Kong, Jie
    Wang, Qing Yin
    Wang, Wei Ji
    Meng, Xian Hong
    AQUACULTURE INTERNATIONAL, 2011, 19 (05) : 873 - 889
  • [49] PURIFICATION AND PROPERTIES OF GLUTAMINE-SYNTHETASE FROM THE ARCHAEBACTERIUM HALOBACTERIUM-SALINARIUM
    MANITZ, B
    HOLLDORF, AW
    ARCHIVES OF MICROBIOLOGY, 1993, 159 (01) : 90 - 97
  • [50] Purification and properties of glutamine synthetase from Hydrogenobacter thermophilus TK-6
    Kameya, Masafumi
    Arai, Hiroyuki
    Ishii, Masaharu
    Igarashi, Yasuo
    JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 2006, 102 (04) : 311 - 315
12345